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EC number: 204-815-4
CAS number: 126-97-6
terminal body weight decreased by 7% and 5% at the dose levels of 90
mg/kg and 180 mg/kg respectively (Table R-1). The absolute and relative
weights of male reproductive organs were all comparable across groups
(Table R-1). The percent motility, the number of sperm per mg cauda, the
total number of sperm per cauda, the number of spermatids per mg testis,
and the total number of spermatids per testis were all comparable across
all groups (Table R-2).
The female terminal body weight was comparable across all groups (Table
R-3). The evaluation of vaginal smears revealed no significant
differences among the females in the cycle length, number of cycles,
number of cycling females, or number of females with regular cycles
(Table R-4). The relative amount of time spent in oestrous stages was
heterogeneous among treatment groups, but the pair-wise comparisons
between each dosed group and the control group were not significant.
The purpose of this
study was to determine if exposure to sodium thioglycolate (NaT) affects
the reproductive system by evaluating sperm parameters and vaginal
cytology data. The potential toxic effects of this compound on male and
female rat reproductive system was tested by evaluation sperm parameters
and vaginal cytology data.
Four groups of Sprague
Dawley rats (10 males and 10 females) were treated with sodium
mercaptoacetate at 0, 45, 90, 180 mg/kg bw/d. Sodium mercaptoacetate was
applied on skin during 13 weeks, 5 days a week.
For males, data sheets
which included body weights, sperm density, sperm motility, whole left
epididymal, left cauda epididymal, and left testicular weights were
provided. Spermatids in the parenchyma were counted. For females, the
vaginal cytology slides were evaluated and the oestrous cycle stage
(Prooestrus, Oestrus, Metoestrus or Dioestrus) was determined for each
day. The cycle length, number of cycles, number of cycling females, and
number of females with a regular cycle were determined.
No effects with
statistically significance were observed at any doses, neither males nor
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