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EC number: 204-815-4
CAS number: 126-97-6
No data is available on the carcinogenic
potential of MeaTG by the oral and inhalation routes.
In a non-standard study by dermal route,
sodium mercaptoacetate was administered to mice as 0, 1.0 and 2.0%
solutions, until all animals died. Differences in the life span and the
incidence of neoplasms between experimental and negative control mice
were not statistically significant.
to the available carcinogenicity data, no classification is warranted
for mercaptoacetic acid and its salts.
carcinogenicity data is available on mercaptoacetic acid and its salts
by the inhalation or oral routes. The information on the carcinogenicity
potential of mercaptoacetic acid and its salts is limited to a study in
mice by chronic cutaneous application of sodium mercaptoacetate.
carcinogenicity of sodium mercaptoacetate was evaluated using 94 Swiss
female mice (7 weeks old) from the Eppley colony. 0.02 ml of a 1.0 and
2.0 % solutions of sodium mercaptoacetate in acetone (equivalent to dose
levels of 6.6 and 13.3 mg/kg bw) were applied twice per week to the
shaved skin (interscapular region) of each of the 49 or 45 mice,
respectively. Ninety-three mice served as negative controls. Positive
control groups, 40 mice, were treated with
7,12-dimethylbenz-[a]-anthracene. None of the experimental or control
mice survived beyond week 120 of treatment. Infectious diseases, such as
pneumonia and hepatitis, occurred in a small number of animals,
resulting in an increased number of deaths. Large numbers of neoplasms
were observed in treated and negative control mice: lymphomas, pulmonary
adenomas, hepatic hemangiomas, ovarian neoplasms, and dermal fibromas.
Epidermal neoplasms were not observed. Differences in the incidence of
neoplasms between experimental and negative control mice were not
statistically significant. No significant decrease in the life span of
mice in experimental groups was observed. The authors concluded that
sodium mercaptoacetate was not carcinogenic (Stenback et al.,
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