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EC number: 204-815-4
CAS number: 126-97-6
Default (DNEL calculator)
thioglycolate (NaTG) was chosen for long-term animal studies to act as
an appropriate surrogate for thioglycolic acid and its salts. Correcting
the NOAEL for molecular weight is regarded as not necessary, as it has
only minor effects on this value and finally on the DNELs.
systemic effects, long-term exposure
a 90-day oral toxicity study performed in rats with NaTG, a NOAEL of 20
mg/kg bw/day for systemic toxicity has been determined.
Step 1) Relevant dose descriptor
NOAELRat= 20 mg/kg bw/day
Step 2) Modification of starting point
Conversion into inhalatory NOAEC (in mg/m³) by using an 8-hour standard respiratory volume for the rat
Correction for differences between oral and inhalation absorption
Correction for differences in 8-hour inhalative volumes between workers in rest and workers under light activity
0.38 m³ /kg bw
6.7 m³ / 10 m³
Step 3) Assessment factors
Quality of database
(20 x 1/0.38 x 1 x 6.7/10 x 1/(2.5 x 7 x 5 x 2 x 1 x 1))
difference between oral and inhalation absorption is assumed.
available data suggests no relevant differences in dermal absorption
among the salts of the thioglycolic acid.
90-day studies performed in rats and mice with NaTG, the dermal NOAELs
for systemic toxicity were higher than 180 and 360 mg/kg bw/day,
respectively. The NOAEL > 360 mg/kg bw/day determined in mice is
selected as a relevant dose-descriptor.
NOAELMouse> 360 mg/kg bw/day
Correction for substance differences in dermal absorption
2.5 x 7
> 2.06 mg/kg bw/day
(360 x 1/(2.5 x 7 x 5 x 2 x 1 x 1))
a 90-day dermal toxicity study perfomed in rats with NaTG, the LOEL for
local effects at the site of application (skin irritation) was 11.25
LOELRat= 11.25 mg/kg bw/day
Modification to LOEL for dermal irritation (in mg/cm²/day)
0.25 kg / 44.5 cm²
Interspecies (local effects)
Dose response (LOEL/NAEL extrapolation)
(11.25 x 0.25/44.5 x 1/(1 x 5 x 1 x 3 x 1))
for the general population have not been proposed because thioglycolates
are generally used as an ingredient in cosmetic products. According to
Article 14, paragraph 5(b) of Regulation No. (EC) 1907/2006 (REACh), the
chemical safety report does not need to include considerations of the
risk to human health from end uses in cosmetic products within the scope of
Regulation (EC) No. 1223/2009 (Cosmetics
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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