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EC number: 200-441-0 | CAS number: 59-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- RCC AG
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Nicotinic acid
- EC Number:
- 200-441-0
- EC Name:
- Nicotinic acid
- Cas Number:
- 59-67-6
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nicotinic acid
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material: Nicotinic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: males: 7 week s; females: 9 weeks
- Weight at study initiation: males: 208 - 226 g; females: 170 - 191 g
- Fasting period before study: None.
- Housing:Macrolon cages Type 2, with wire mesh lids
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: 1 week under test conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 °C
- Humidity (%): 55 +/- 10
- Photoperiod: 12 hours/day
IN-LIFE DATES: From: 10 Aug. 1983 To: 24 Aug. 1983
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 2 %
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 20 cm2
- % coverage: 100
- Type of wrap if used: Occlusive dressing which was fixed by an adhesive elastic bandage wrapped around the trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The skin was cleaned with lukewarm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4 ml
- Concentration (if solution): 2000 mg/kg bw
- Constant volume or concentration used: Yes
VEHICLE
- Amount(s) applied (volume or weight with unit): 4 ml - Duration of exposure:
- Single exposure of 24 h.
- Doses:
- 2000 mg/kg bw (limit test)
- No. of animals per sex per dose:
- 5 male/5 female
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Mortality: Five times during the first day, and daily thereafter.
Body weights:Body weights were recorded at the day of administration and days 8 and 15 of test.
Symptoms: Five times at day 1, and daily for the nature, onset, severity and duration of all gross or visible toxic or pharmacologic effects and time of death.
- Necropsy of survivors performed: Yes - Statistics:
- The LOGIT Model could not be applied to the observed rates of death. The LD50 was estimated without use of a statistical model.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed during the observation period.
- Clinical signs:
- other: No clinical signs observed during the observation period.
- Gross pathology:
- No treatment related effects observed.
- Other findings:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity study with rats (5 male/5 female Wistar) a single dose of 2000 mg/kg bw (occlusive) was administered. Following a 24 h exposure period and washing of exposed skin, animals were observed for 14 days. The LD0 obtained for males/females was 2000 mg/kg bw. The LD50 for males/females was > 2000 mg/kg bw. The test item was considered practically non-toxic.
- Executive summary:
A study according to OECD Guideline 402 (Acute dermal toxicity) was carried out. Groups of rats (5 male/5 female Wistar) were administered a single dose of 2000 mg/kg bw (occlusive). Following a 24 h exposure period and washing of exposed skin, animals were observed for 14 days. The LD0 obtained for males/females was 2000 mg/kg bw. The LD50 for males/females was > 2000 mg/kg bw. The test item was considered practically non-toxic.
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