Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 950-627-7 | CAS number: 1042950-30-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -2.25
- Temp.:
- 22.5 °C
- pH:
- 7
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.27
- Temp.:
- 22.5 °C
- pH:
- 9
- Conclusions:
- For pH 4, no test item could be determined for the octanol phase and thus no partition coefficient could be calculated. Taking the LOQ level (850 µg/L) into account, it can be concluded, that the partition coefficient is below a value of -3.9.
For pH 7, the values for the different n-octanol : buffer ratio were inhomogeneous and thus not fulfilling the validity criterion. The pH value of the aqueous phases did differ as well, with higher pH values for the runs with the most test item in the respective system. The partition coefficient correlates strongly with the pH value of this aqueous phase showing a higher partition coefficient at higher pH values, verifying a strong dependency of the partition coefficient from the pH.
pH 7 : log Pow - 2.25
For pH 9, the six determined log POWvalues did not differ for more than 0.13, fulfilling the validity criterion (log POWshould not differ for more than 0.3).
pH 9 : log Pow 0.27 - Executive summary:
For pH 4, no test item could be determined for the octanol phase and thus no partition coefficient could be calculated. Taking the LOQ level (850 µg/L) into account, it can be concluded, that the partition coefficient is below a value of -3.9.
For pH 7, the values for the different n-octanol : buffer ratio were inhomogeneous and thus not fulfilling the validity criterion. The pH value of the aqueous phases did differ as well, with higher pH values for the runs with the most test item in the respective system. The partition coefficient correlates strongly with the pH value of this aqueous phase showing a higher partition coefficient at higher pH values, verifying a strong dependency of the partition coefficient from the pH.
pH 7 : log Pow - 2.25
For pH 9, the six determined log POWvalues did not differ for more than 0.13, fulfilling the validity criterion (log POWshould not differ for more than 0.3).pH 9 : log Pow 0.27
Reference
Description of key information
For pH 4, no test item could be determined for the octanol phase
and thus no partition coefficient could be calculated. Taking the LOQ
level (850 µg/L) into account, it can be concluded, that the partition
coefficient is below a value of -3.9.
For pH 7, the values for the different n-octanol : buffer ratio were
inhomogeneous and thus not fulfilling the validity criterion. The pH
value of the aqueous phases did differ as well, with higher pH values
for the runs with the most test item in the respective system. The
partition coefficient correlates strongly with the pH value of this
aqueous phase showing a higher partition coefficient at higher
pH values, verifying a strong dependency of the partition coefficient
from the pH.
pH 7 : log Pow - 2.25
For pH 9, the six determined log POWvalues did not
differ for more than 0.13, fulfilling the validity criterion (log POWshould
not differ for more than 0.3).
pH 9 : log Pow 0.27
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.25
- at the temperature of:
- 22.5 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.