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Diss Factsheets
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EC number: 948-935-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzenesulfonic acid, C14-24-alkyl derivatives, magnesium salts, overbased
- Molecular formula:
- Not applicable - UVCB
- IUPAC Name:
- Benzenesulfonic acid, C14-24-alkyl derivatives, magnesium salts, overbased
- Test material form:
- solid
Constituent 1
Results and discussion
- Dissociating properties:
- not determined
Dissociation constant
- Remarks on result:
- not determinable
- Remarks:
- Due to test material being insoluble in water and only sparingly soluble in one water-miscible solvent (THF), the determination of the dissociation constant by OECD 112 was not possible.
Any other information on results incl. tables
- All three methods listed in OECD 112 require the chemical substance to be dissolved in water. The expected water solubility of the test material is <1 mg/mL, therefore the test material is only sparingly soluble in water. In cases where the test material is only sparingly soluble in water, OECD 112 allows for the use of a small amount of water-miscible solvent to dissolve the test material prior to addition to water. The final concentration should not exceed the lesser of 0.01 M or half the saturation concentration.
- The only water-miscible solvent in which the test material was observed to be soluble was THF, and only to a maximum solubility of ~1 mg/mL. A test solution with a target test material concentration of 0.1 mg/mL was therefore prepared from a 1 mg/mL solution of the test material in THF by 10-fold dilution into water. The resulting solution was composed of 10% THF, beyond what may be considered a small amount (≤1%) of water-miscible solvent by OECD 112. Additionally, small amounts of solid precipitate could be observed, indicating that the target concentration of 0.1 mg/mL was well in excess of half the saturation concentration.
Applicant's summary and conclusion
- Conclusions:
- Due to the test material being insoluble in water and only sparingly soluble in one water-miscible solvent (THF), the determination of the dissociation constant by OECD 112 was not possible. For this reason, a waiver from OECD 112 testing is requested.
- Executive summary:
The test material, is a pale yellow solid. During preliminary evaluation of solvent solubility, the test material was found to be insoluble in water and most common organic solvents, with the exception of chloroform and tetrahydrofuran (THF).
OECD 112 lists three methods for determining the dissociation constant of a compound in water (titration, spectrophotometric, conductometric), all of which require the chemical substance to be dissolved in water. In cases where the test material is only sparingly soluble in water, the use of a small amount of water-miscible solvent is permitted to dissolve the test material prior to addition to water. The final concentration should not exceed the lesser of 0.01 M or half the saturation concentration.
The test material was not observed to be soluble in water at a target concentration of 1 mg/mL. The only water-miscible solvent in which the test material is soluble is THF, and only to ~1 mg/mL. A test solution with a target test material concentration of 0.1 mg/mL was prepared from a 1 mg/mL solution of the test material in THF by 10-fold dilution into water. The resulting solution was 10% THF, beyond what may be considered a small amount (≤1%) of water-miscible solvent by OECD 112. Additionally, small amounts of solid precipitate could be observed, indicating that the target concentration of 0.1 mg/mL was well in excess of half the saturation concentration.
Due to the lack of solubility of the test material in water, a waiver from OECD 112 testing is requested.
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