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Diss Factsheets
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EC number: 947-724-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07-15 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected on 15 and 16 November 2017 / signed on 15 May 2018
- Type of method:
- differential scanning calorimetry
- Boiling pt.:
- >= 147.81 - <= 309.07 °C
- Atm. press.:
- >= 995.9 - <= 996.8 mBar
- Decomposition:
- yes
- Decomp. temp.:
- >= 311.93 °C
- Conclusions:
- Boiling of the major part of the substance was stated as 147.81 °C to 309.07 °C (420.96 K to 582.22 K).
Decomposition of the substance was observed by DSC from approximately 311.93°C (585.08 K) (exothermic deviation of the baseline).
For information purpose, the last event was evaluated for decomposition energy at 103.59 J/g between 325.8 °C and 450°C. - Executive summary:
A study was conducted to determine the boiling point of the test substance under GLP according to OECD 103 / EU A2 guideline.
The determination of boiling point was determined via DSC (differential scanning calorimetry).
Four DSC determinations were conducted and the observations reported during the pre-test performed according the Siwoloboff method have also been used to interpret the results obtained with the DSC method.
In the four DSC measurements, one flat and broad endothermic peak was observed between 46.28 and 155.81°C (319.43 K – 428.96 K). This event can be assigned to a kind of transition leading to a form more flowable than the original test item at room temperature. The evaporation / boiling of the most volatile minor compounds of the complex substance should also be observed in this peak.
In the second to fourth DSC measurements, a second flat and broad endothermic peak was observed between 147.81 and 309.07°C. This event was interpreted as the boiling of the major part of the substance and the boiling range of the test item was stated as 147.81 °C to 309.07 °C (420.96 K to 582.22 K)
Finally, a turbulent baseline deviating toward exothermic events was observed from approximately 311.93°C (585.08 K). This deviation of the baseline was interpreted as the beginning of the decomposition of the test item after boiling.
Reference
First, a pre-test following Siwoloboff method was performed.
According to the observations reported during the pre-test, we noted that:
- at 80°C, the test item is more flowable than the original test item.
- from 110°C, small bubbles at the surface were visible, which may be due to the evaporation / boiling of the more volatile compounds of the complex substance.
- Between 110°C and 184°C individual bubbles were observed followed by boiling of the test item with small bubbles at the surface and big bubbles from the bottom
- At 184°C, test item boiled with big bubbles. Heating plate was turned off.
- At 182°C, superheating was observed and there were no bubbles anymore at 160°C.
=> Boiling point of the major part of the substance was anticipated from about 160°C. This temperature may be considered as the initial boiling point of the major part of the substance estimated in the pre-test.
The test item was visually like the original test item after the pre-test.
Then, four determination were performed using the DSC method. All the values were evaluated with event marker function.
In the first determination (from 25°C to 200°C), only one endothermic event was observed between 46.28°C and 140.23°C. However no event was observed from the expected initial boiling point determined in the pre-test (160°C). Therefore the temperature program of further determinations was adapted (25 °C to 445 °C).
In the other determinations, two flat and broad peaks were detected corresponding to two endothermic events.
The first one was observed between 48.37 and 155.81°C.
This event can be assigned to a kind of transition leading to a form more flowable than the original test item at room temperature. This was confirmed by the observation reported in the pre-test, i.e. at 80°C, the test item is more flowable than the original test item.
However, we noted that during the pre-test, small bubbles at the surface were visible from 110°C, which may be due to the evaporation / boiling of the most volatile minor compounds of the complex substance. This was confirmed by the mass loss observed (2.24%) after the first DSC measurement (after heating up to 200°C). Therefore, the flat and broad endothermic peak observed in this temperature range can cover several types of transition.
The second event was observed between 147.81 and 309.07°C in the second to fourth measurements.
This temperature range matched with the initial boiling point of the major part of the substance estimated in the pre-test (160°C).
No signs of decomposition were reported up to 184°C (see pre-test observation).
After the test (after heating up to 445°C), a mass loss between 87.7 and 95% was reported.
This event was interpreted as the boiling of the major part of the substance and the boiling range of the test item was stated as 147.81 °C to 309.07 °C (420.96 K to 582.22 K)
Finally, a turbulent baseline, deviating toward exothermic events was observed from approximately 311.93°C.
This can be the sign of decomposition of the test item.
Note: that after the test, the fourth crucible was opened and the test item smelled like motor oil, which might indicate a decomposition of the test item during the measurments.
No observations were made which might cause doubts on the validity of the study outcome. Therefore the result of the study is considered valid.
Description of key information
Boiling of the major part of the substance was stated as 147.81 °C to 309.07 °C (420.96 K to 582.22 K).
Decomposition of the substance was observed by DSC from approximately 311.93°C (585.08 K) (exothermic deviation of the baseline).
For information purpose, the last event was evaluated for decomposition energy at 103.59 J/g between 325.8 °C and 450°C.
Key value for chemical safety assessment
Additional information
A fully reliable GLP experimental study, conducted according to a recognized OECD/EC guidelines is available.
It is considered as a key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.