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EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 11268-2 (Effects of Pollutants on Earthworms. 2. Determination of Effects on Reproduction)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
- Remarks:
- Quartz sand
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Remarks:
- 10% Sphagnum-peat, 20% Kaolin clay, 69.5% fine quartz-sand and 0.5% Calcium carbonate
- Total exposure duration:
- 56 d
- Remarks:
- Adults were exposed for 28 days. After 4 weeks, adults were sorted from the soil and weighed. They were not placed back into the boxes. Juveniles which had been produced in the boxes remained in the soil for another 4 weeks without further feeding.
Test conditions
- Test temperature:
- 18.0 - 22.0°С
- pH:
- 5.8 to 6.0 at test start and 5.8 to 5.9 at test termination
- Moisture:
- Initiation: 32.8% to 33.5% (equivalent to 53.7% to 54.9% of the maximum water holding capacity) Termination: 32.7% to 35.7% (equivalent to 53.6% to 58.5% of the maximum water holding capacity)
- Nominal and measured concentrations:
- Nominal: 6.36, 12.73, 25.46, 50.92 and 101.8 mg test item/kg dry artificial soil (corresponding to 6.25, 12.5, 25.0, 50.0 and 100 mg/kg dry artificial soil, adjusted for purity)
- Reference substance (positive control):
- yes
- Remarks:
- Carbendazim (tested once per year)
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 28 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: highest concentration tested
- Duration:
- 56 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: overall
- Duration:
- 56 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 100 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: overall
- Results with reference substance (positive control):
- The EC50 for reproduction of the reference item in the most recent test was 1.87 mg carbendazim/kg dry artificial soil. All validation criteria were within acceptable limits indicating the validity of this test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 28 days LC50 (Earthworm): >100 mg/kg dry artificial soil, the highest concentration tested
NOEC Earthworm (overall): 50.0 mg/kg dry soil
LOEC Earthworm (overall): 100 mg/kg dry soil - Executive summary:
The sublethal toxicity of the test item to earthworms, Eisenia fetida, was determined in a 56-day soil exposure laboratory study according to OECD 222, 2004 and ISO 11268-2, 2012. Adult earthworms were exposed to artificial soil (prepared according to OECD 222) treated with the test item to obtain the nominal concentrations of 6.36, 12.73, 25.46, 50.92 and 101.8 mg test item/kg dry artificial soil (corresponding to 6.25, 12.5, 25.0, 50.0 and 100 mg/kg dry artificial soil, adjusted for purity) and to an untreated control (quartz sand and deionized water only). Mortality and growth (body weight) of the earthworms were assessed after 28 days and the effect on reproduction (number of juveniles produced) was assessed after 56 days.
The test item had no statistically significant lethal effects or effects on growth or feeding activity of the earthworm Eisenia fetida when exposed to concentrations up to and including 100 mg/kg dry artificial soil.
Reproduction was not statistically significantly reduced up to and including 50.0 mg/kg dry artificial soil.
The overall NOEC (No-Observed-Effect Concentration) was determined to be 50.0 mg/kg dry artificial soil and the overall LOEC (Lowest-Observed-Effect Concentration) was determined to be 100 mg/kg dry artificial soil.
The LC50 after 28 days was estimated to be greater than 100 mg/kg dry artificial soil, the highest concentration tested.
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