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EC number: 939-488-3 | CAS number: 1471311-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (INBIFO, 1979): irritating
Eye irritation (INBIFO, 1979): serious eye damage
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
The skin irritation potential of the test substance (ca. 0.5 ml) was tested in a Draize-Test on the shaved and intact skin for 24 hours under occlusive conditions in six rabbits (INBIFO, 1979). The skin reactions were scored comparable to the scoring system reported in OECD 404 guideline after 24 and 72 hours. The skin was examined for a total of 7 days. The mean erythema score (24/72 hours) was 1.92, the mean edema score (24/72 hours) was 2.59. The individual mean erythema scores in the animals were: 1 in 1/6 animals, 2 in 4/6 animals, 2.5 in 1/6 animals. The individual mean edema scores in the animals were: 2 in 4/6 animals, 3.5 in 1/6 animals, 4 in 1/6 animals. Based on these results, the test substance was irritating to the skin.
When the test substance (ca. 0.5 ml) was tested on the shaved and intact skin for 5 minutes (open conditions) and 2 hours (occlusive conditions) in two rabbits (BASF, 1981), no signs of skin irritation (neither erythema nor edema) were reported 24, 48 and 72 hours post exposure as well as 8 days post exposure. The results show, that the results observed after 24 hours of occlusive exposure might be overpredictive but nevertheless a skin irritation potential has to be assumed as no data is available for a 4 hour exposure periode.
Eye irritation
The eye irriation potential of the test substance (ca. 0.1 ml) was tested in a Draize-Test in six rabbits (INBIFO, 1979). The occular reactions were scored comparable to the scoring system reported in OECD 405 guideline after 24, 48 and 72 hours. The eyes were examined for a total of 7 days, one eye per animal was treated, the other eye served as control. The mean cornea score (24/48/72 hours) was 1.17, the mean iris score (24/48/72 hours) was 0.83, the mean conjunctivae score (24/48/72 hours) was 1.73 and the mean chemosis score (24/48/72 hours) was 2.67. The individual mean cornea scores in the animals were: 0.33 in 2/6 animals, 1 in 2/6 animals, 1.67 in 1/6 animals, 2.67 in 1/6 animals. The individual mean iris scores in the animals were: 0 in 1/6 animals, 1 in 5/6 animals. The individual mean conjunctivae scores in the animals were: 0.67 in 1/6 animals, 1.67 in 1/6 animals, 2 in 4/6 animals and the individual mean chemosis scores in the animals were: 0.67 in 1/6 animals, 1 in 1/6 animals, 2.33 in 2/6 animals, 3 in 1/6 animals, 3.67 in 1/6 animals. As the cornea and iris lesions were not fully reversible at the end of the observation period of 7 days, the test substance poses the risk of serious damage to the eye. It is hower unknown if the observed effects would have been reversible after a 21 day observation periode.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the available data, a classification as irritating to the skin (R38 according to Directive 67/548/EECand Skin Cat. 2 according to the CLP Regulation (EC) No. 1272/2008) and posing the risk of serious eye damage (R41 according toDirective 67/548/EEC and Eye Cat. 1 according to the CLP Regulation (EC) No. 1272/2008) is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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