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EC number: 603-923-2 | CAS number: 135590-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Jun 1992 - 15 Jun 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Study type:
- direct photolysis
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-2 (Photodegradation Studies in Water)
- GLP compliance:
- yes
Reference
Findings:
The total recovery of samples for all series was in a range of 99.6 to 106.6% of applied radiolabel with the exception for one sample of dark controls (85.7% for final sampling interval).
By the end of the incubation, volatile components were detected between 0.5% (dark controls) and 13.4% (mean value of the two irradiation series).14C-carbon dioxide was formed at 0.1% (dark controls) to 6.3% (mean value for irradiated samples) of applied radioactivity.
Besides the parent compound, one predominant photodegradation product with reporting title “Peak 9”was observed at peak values of approx. 40% by the end of the experiment. Co-chromatography of samples showed that P9 was identical with a major unknown observed in soil photolysis with reporting title “M8”.
Efforts on the structural elucidation of “Peak 9” resulted in three structural proposals of which an 2,3-oxaziridine structure in the heterocycle was proposed as the preferred structure explaining best all results from spectroscopical work .
At least nine additional components were observed, none of them amounting to more than 8.4% in maximum in the course of the experiment.
The UV spectrum of the parent compound AE F107892 shows very limited adsorption at wave lengths of more than 290 nm. This is supported by findings of low mean values for the quantum yield with 2.53 x 10-5and 2.45 x 10-5for the two Suntest photoreactors used.
The experimental half-lives for photolysis were corrected by the relative photon flux of the photoreactors given as hours sunshine at 52° Northern latitude per instrument hours. In addition, the half-lives were normalised to a daily sunshine duration of 12 hours. The calculated half-lives for photolysis (DT50 calc) of mefenpyr-diethyl are summarized in the Table
Corrected half-lives of photolytic degradation of AE F107892 for the Northern Hemisphere
Sterile aqueous acetate buffer, pH 5 |
DT50 calc. |
DT50 calc. |
Photoreactor SUNTEST II |
193.5 |
16.5 |
Photoreactor SUNTEST III |
200 |
17 |
1: rounded values
Conclusion:
The contribution of aqueous photolysis to the overall degradation of AE F107892 is regarded as moderate to low due to the low quantum yields (2.5 x 10-5) of the compound. The dissipation of the parent compound (DT-50 = 16.5 days) is accompanied by the formation of a large number of minor products, each observed at peak values of less than 10% of the applied radiolabel besides the formation of14C-carbon dioxide and other non-polar volatiles.
A major product was observed at maximum values of 40%. The investigations for structural elucidation resulted in structural proposals very similar to the parent compound, see 2,3-oxaziridine derivative, of which the formation can be explained by an addition of an oxygen atom to the parent compound.
This suggests that reactive oxygen species may be formed in the irradiated water. The oxygen species may be the major reactants with the dissolved molecules of AE F107892 rather than a direct interaction of the compound with the photons of the light. Under environmental conditions, the formation of photolytically induced metabolites is less pronounced due to the very low half-life of the parent compound as a precursor under biotic conditions.
Photodegradation products are therefore not regarded as a significant degradation pathway for the elimination of mefenpyr-diethyl from the aquatic environment.
Description of key information
Photodegradation processes are not regarded to contribute significantly to the elimination of the substance from the aquatic environment.
Key value for chemical safety assessment
- Half-life in water:
- 17 d
Additional information
The photogedradation of the substance in water was determined in a study following EPA Guideline Subdivision N 161-2 (1994). The determined environmental half-life (52° Northern latitude) was 17 days for sterile aqueous photolysis. The photolysis is accompanied by the formation of a number of minor products one major product as well as the formation of 14C-carbon dioxide and other non-polar volatiles. Considering the rapid biotic hydrolysis of the parent substance in surface water and the low quantum yield determined for photolytic conversions, the formation of photolytic induced transformation products is much less pronounced for the outdoor aquatic environment. The direct photolysis is therefore not of significance for the elimination of the substance from the aquatic environment.
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