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Diss Factsheets
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EC number: 610-877-7 | CAS number: 52624-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin
In vivo
- Rabbit, 4 h, semiocclussive: not irritating to skin (OECD 404; BASF AG 1988)
Eye
In vivo
- Rabbit, 24 h, substance was not washed out: Risk of serious damage to eyes (OECD 405, BASF AG 1988)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin
In a skin irritation test according to OECD guideline 404, a 0.5 ml aliquot of the test substance was applied under a 2.5 cm square gauze pad to one intact skin site on each of three animals (BASF AG, 1988). The test material was applied under semiocclusive conditions for 4 hours. Grading and scoring of the dermal reactions were performed using the scoring system according to Draize. The single semi-occlusive application of the test substace to intact rabbit skin for four hours did not lead to any signs of irritation. Neither erythema nor edema was observed after 24, 48 and 72 hours.
Eye
The test substance was examined for its eye irritation potential according to OECD Guideline 405. The test concentration was 0.1 ml test substance per eye (BASF AG, 1988). Effects were examined after 1, 24, 48 and 72 hours as well as after 8, 15 and 21 days post application. Based on the results, the test substance has to be classified as posing a risk of serious damage to eyes due to the fact that corneal opacity, redness of the cojunctivae and chemosis were still observed at the end of the observation period in 1/3 animals. Corneal opacity was first observed 8 days post exposure. The mean scores (24/48/72 hours) for all three animals were 0 for corneal opacity, 1.88 for redness of the conjunctivae (2.33, 1.33 and 2 for the individual animals), 0.78 for chemosis (1.33, 0 and 1 for the individual animals) and 0.11 for iris lesions (0.33, 0 and 0 in the individual animals).
Effects on eye irritation: corrosive
Justification for classification or non-classification
Skin
According to the results of the available test, the test substance is not irritating to the skin according to EU and GHS-requiremnets (67/548/EEC and 1272/2008/EC).
Eye
According to the available test result, the test substance has to be classified as posing a risk of serious eye damage (R41/Eye Cat.1) following EU (67/548/EEC)- and GHS (1272/2008/EC) requirements.
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