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Diss Factsheets
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EC number: 680-341-5 | CAS number: 41438-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Absorption rate - dermal (%):
- 32.5
Additional information
According to data available by oral route in the acute oral toxicity study at 2000 mg/kg bw and in developmental toxicity study (OECD 414) at doses of 100, 300 and 1000 mg/kg bw/day, MEXORYL SBU can be considered as without any toxic effect.
In vitro skin penetration of MEXORYL SBU was performed through human dermatomed skin and rat full thickness skin over a 24 hour exposure period with a formulation containing a nominal 5 % MEXORYL SBU.
The results obtained in this study indicate that MEXORYL SBU penetrated through human and rat skin at a slow rate from a 5 % MEXORYL SBU test preparation. The extent of penetration through human and rat skin amounted to 27.9 % (140μg/cm2) and 20.4 % (102μg/cm2), respectively after 24 hours.
For both human and rat skin, a large proportion of the applied dose remained on the skin surface after a 24 hour exposure interval and was readily removed by a gentle skin washing procedure. Low proportions of the dose were associated with the stratum corneum and remaining epidermal membranes.
The total systemically available value (epidermis plus dermis and receptor fluid) was similar for human and rat skin and represented 32.5 % and 32.4 % of the applied dose, respectively (corresponding to 162μg/cm² and 162μg/cm², respectively). Considering that the dermal penetration decrease with the increase of the concentration, the 32.5% of dermal penetration obtained with preparation at 5% was considered as conservative value to evaluate the skin penetration of Mexoryl SBU.
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