Phenol, ethoxylated, esters with acrylic acid

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Analysis of closely structural substances. For further justification se document attached in section 13.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Deviations:

yes

Remarks:

Read-across to studies with other similar substances

Principles of method if other than guideline:

Read-across to 21-d studies on Daphnia magna for other substances with similar structures has been done. The toxic mode of action is identified to be the acrylate part of the substance.

GLP compliance:

yes

Remarks:

Assumed to be performed in accordance to GLP

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
not relevant

Details on sampling:

not relevant

Vehicle:

not specified

Details on test solutions:

not relevant

Test organisms (species):

Daphnia magna

Details on test organisms:

not relevant

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

21 d

Post exposure observation period:

not relevant

Hardness:

not relevant

Test temperature:

not relevant

pH:

not relevant

Dissolved oxygen:

not relevant

Salinity:

not relevant

Nominal and measured concentrations:

not relevant

Details on test conditions:

not relevant

Reference substance (positive control):

not specified

Key result

Duration:

21 d

Dose descriptor:

EC10

Effect conc.:

> 0.1 mg/L

Nominal / measured:

not specified

Conc. based on:

dissolved

Basis for effect:

reproduction

Details on results:

Weight of evidence.

Results with reference substance (positive control):

Read-across study, i.e. no reference substance

Validity criteria fulfilled:

not applicable

Conclusions:

Based on read-across an EC10 (crustacean, 21 d) of 0.1 mg/L was derived.

Executive summary:

Read-across to 21-d studies on Daphnia magna of other substances with similar structures (OECD Guideline 211 (Daphnia magna Reproduction Test) has been prepared. done. Methyl-acrylate, Ethyl acrylate, Butylacrylate, 2-ethylhexyl acrylate, Hydroxyethyl acrylate, 2-phenoxyethanol,  The toxic mode of action was identified to be associated mainly with the acrylate part of the substance and the logPOW. Based on this, there is a weight-of-evidence of that the EC10 of >0.1 mg/L.

Description of key information

21-day long-term NOEC values for the toxicity (reproduction) of Phenol, ethoxylated, esters with acrylic acid to the freshwater Daphnia magna was established on the basis of read-acorss to 5 other substances with a structure contained in Phenol, ethoxylated, esters with acrylic acid. Test guideline followed for the 5 substances was OECD Guideline 211 (Daphnia magna Reproduction Test) or similar. 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.1 mg/L

Additional information

21-day long-term NOEC values for the toxicity (reproduction) of phenoxyethylacrylate to the freshwater Daphnia magna was established on the basis of read-across to 5 other substances with a structure contained in phenoxyethyl acrylate ( 2-phenoxyethyl acrylate (48145-04-6); methylacrylate (96-33-3), Ethylacrylate (140-88-5), butylacrylate (97-88-1), 2-hydroxyethyl acrylate (818-61-1)methacrylic acid, monoester with propane-1,2-diol (25584-83-2) and 2-phenoxyethanol (122-99-6)). Test guideline followed for the 7 substances was OECD Guideline 211 (Daphnia magna Reproduction Test) or similar.