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Diss Factsheets
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EC number: 290-924-2 | CAS number: 90294-40-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
One study on analogue substance 1 was performed for in-vivo skin sensitization following OECD 406 (Huntsman, 1995).
The test was performed in the albino Hartley guinea-pig, to evaluate skin sensitisation of the test substance using the GPMT protocol according to Magusson and Kligman. In total 30 animals of both sexes were used, allocated to one control group of 10 animals (induction : vehicle - challenge : test article) and one treated group of 20 animals (induction and challenge : test article).
Animals were exposed to test article by 3 series of 2 X 0.1 ml injections. Test solution was made as 0.1% (W/W) solution in water for injection.
During the preliminary study, the test article tinted the skin of the animals thus making observations of erythema impossible. Nevertheless, as no oedema was noted, a skin painting was performed during the main study on Day 8, with 0.5 ml of sodium lauryl sulphate at 10% (W/W) in Codex paraffin to create irritation.
After a rest period of 11 days, a challenge was performed with the topical occlusive application for 24 h in treated and control group with the test article in a 1% (W/W) solution in water for injection and at the dose level of 0.5 ml (Maximum Non-irritant concentration)
The cutaneous macroscopic examination was performed 24 and 48 h after removal of the patches to the challenge application site, according to the Magnusson & Kligman scale. As the test article tinted the skin of the animals, thus making observations of erythema impossible, histopathological examination of the skin were performed for all the animals of the treated and control groups.
Signs of irritation were noted during induction after application of sodium lauryl sulphate in both groups. After challenge, the macroscopic and histopathological examinations did not reveal any lesion of delayed hypersensitivity in the 20 treated animals. No relevant cutaneous abnormality was noted in the 10 guinea-pigs examined in the control group.
From the results obtained under the experimental conditions employed, the test article did not provoke any reaction of cutaneous sensitization in the animals examined.
Hence, the test substance is regarded as non-sensitizer.
Based on the read across considerations same results apply to Acid Orange 144.
Justification for classification or non-classification
According to Regulation 1272/2008 a substance tested following OECD 406 (GPMT) is classified as:
skin sens cat 1: < 0.1 intradermal, >30%
>0.1 to <1% intradermal, >60%
Skin sens cat 2: >0.1 to <1% intradermal >30 to <60%
>1% intradermal >30%
Based on the above results the substance is not classified as skin sensitizer.
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