Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 274-157-0 | CAS number: 69851-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Justification for type of information:
- Additional documentation, provided within the IUCLID Assessment Reports (Section 13), supports the read-across approach.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- only 24 hour evaluations were performed; the highest vehicle concentraton was 147.7 mg/L
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- alkylphenol-polyglykol-ether
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 4.0 g TK 10015 and 40 mg alkylphenol-polyglykol-ether were mixed with and made up to 10 mL with DMF. This solution was diluted to 100 mg/L with water.
with water.
- Controls: water and vehicle
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): alkylphenol-polyglykol-ether
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)): 146.7 mg DMF and 1 mg alkylphenol-polyglykol-ether per liter water in the concentration used for the highest test concentration was used as vehicle control
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): Small parts of the test substance were swimming at the surface of the test solutions at concentration of 10-100 mg/L (nominal) from the start of the test. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: Daphnia magna Straus 1820
- Source: CIBA-GEIGY Ltd., Facilities, Basle
- Age of parental stock (mean and range, SD): (0-24h
- Feeding during test: None
ACCLIMATION
- Type and amount of food: suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract in such quantities that the food is consumed after 24h
- Feeding frequency: three times weekly - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- 240 mg CaC03/L
- Test temperature:
- 20±1°C
- pH:
- 0-hour: 8.1-8.2
24-hour: 8.0-8.2 - Dissolved oxygen:
- 0-hour: 96-98%
24-hour: 101-103% - Nominal and measured concentrations:
- Nominal: 10, 18, 32, 58, 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers covered with watch glasses
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 100 mL solution/beaker
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
OTHER TEST CONDITIONS
- Photoperiod: Fluorescent light, 16 hours daily
- Light intensity: approx. 2000 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobility
VEHICLE CONTROL PERFORMED: yes - Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 82 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: immobility
- Remarks on result:
- other: 95% confidence limits
- Remarks:
- 69-108 mg/L
- Details on results:
- Immobilization was 0, 0, 0, 0, 0, 25, and 65% at 0 (blank), 0 (vehicle), 10, 18, 32, 58, and 100 mg/L.
- Reported statistics and error estimates:
- The EC-50 values were calculated according to BERKSON, JASA 48 (1953), 569-599. EC-values were graphically determined on gausso-logarithmic probability paper.
- Conclusions:
- 24-hour EC50 (Daphnia magna): 82 mg/L
- Executive summary:
The ability of the test substance to cause effects to Daphnia magna was examined in a test in accordance with OECD guideline 202. Twenty Daphnia (4 replicates of 5 Daphnia each) per concentration and control were exposed to nominal concentrations of 10, 18, 32, 58, and 100 mg/L. The 24-hour EC50 was 82 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Justification for type of information:
- Additional documentation, provided within the IUCLID Assessment Reports (Section 13), supports the read-across approach.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Official Journal of the European Communities L 251,vol.27,C-02,19/09/1984.
- Deviations:
- yes
- Remarks:
- No evidence that test concentrations were maintained during exposure.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 200.3 mg test substance were mixed with and made up to 2000 ml
with test water. Calculated amounts of the stock solution to produce the desired test concentrations were given into the water and were homogeneously distributed.
- Controls: blank (water)
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): At 3.2 to 100 mg/L small parts of the test substance were swimming at the surface of the test vessels at all test times. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: Daphnia magna Straus 1820
- Source: CIBA-GEIGY Ltd., Facilities, Basle
- Age of parental stock (mean and range, SD): (6-24h)
- Feeding during test: None
ACCLIMATION
- Type and amount of food: suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract in such quantities that the food is consumed after 24h
- Feeding frequency: three times weekly - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- 240 mg CaC03/L
- Test temperature:
- 20±1°C
- pH:
- 0-hour: 8.1
24-hour: 8.0 - Dissolved oxygen:
- 0-hour: 95-96%
24-hour: 95-100% - Nominal and measured concentrations:
- Nominal: 1.0, 1.8, 3.2, 5.8, 10, 18, 32, 58, 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers covered with watch glasses
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 100 mL solution/beaker
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Photoperiod: Fluorescent light, 16 hours daily
- Light intensity: approx. 1500 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobility - Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 34 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: immobility
- Remarks on result:
- other: 95% confidence limit
- Remarks:
- 22.5-57.3 mg/L
- Details on results:
- Immobilizaztion was 0, 0, 0, 5, 10, 35, 60, 55, 55, and 60% at 0, 1.0, 1.8, 3.2, 5.8, 10, 18, 32, 58, and 100 mg/L.
- Reported statistics and error estimates:
- The EC50 values were calculated according to the maximum likelihood method, probit model (Mc Cullagh, P., Nelder, J.A., 1983: Generalised linear models. Chapman & Hall, London). EC-values were graphically determined on gausso-logarithmic probability paper.
- Conclusions:
- 24-hour EC50 (Daphnia magna): 34 mg/L
- Executive summary:
The ability of the test substance to cause effects to Daphnia magna was examined in a test in accordance with procedures detailed in Official Journal of the European Communities
L 251,vol.27,C-02,19/09/1984. Twenty Daphnia (4 replicates of 5 Daphnia each) per concentration and control were exposed to nominal concentrations of 1.0, 1.8, 3.2, 5.8, 10, 18, 32, 58, and 100 mg/L. The 24-hour EC50 was 34 mg/L.
Referenceopen allclose all
Description of key information
No acute daphnia study with the test substance is available. A study in accordance with OECD Guideline 203 with N,N'-hexane-1,6-diylbis[3-(3,5-di-tert-butyl-4-hydroxyphenylpropionamide] was used as read across to fulfil the data gap for the test substance. The underlying hypothesis supporting read-across from the source (N,N'-hexane-1,6-diylbis[3-(3,5-di-tert-butyl-4-hydroxyphenylpropionamide]; CAS 23128-74-7) to the target (N,N'-propane-1,3-diylbis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionamide]; CAS 69851-61-2) includes the following: (1) Structural similarity, (2) Source and target are expected to hydrolyse in a similar fashion, (3) Source and target have similar predicted metabolism, (4) Source and target have similar physicochemical properties, (5) Source and target have similar calculated chemical descriptors, and (6) Source and target have similar predictions for the endpoints of concern. Additional documentation, provided within the IUCLID Assessment Reports section, supports the read-across approach.
The ability of the test substance to cause effects to Daphnia magna was examined in a test in accordance with OECD guideline 202. Twenty Daphnia (4 replicates of 5 Daphnia each) per concentration and control were exposed to nominal concentrations of 10, 18, 32, 58, and 100 mg/L. The 24-hour EC50 was 82 mg/L.
The ability of the test substance to cause effects to Daphnia magna was examined in a test in accordance with procedures detailed in Official Journal of the European Communities L 251,vol.27,C-02,19/09/1984. Twenty Daphnia (4 replicates of 5 Daphnia each) per concentration and control were exposed to nominal concentrations of 1.0, 1.8, 3.2, 5.8, 10, 18, 32, 58, and 100 mg/L. The 24-hour EC50 was 34 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 34 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.