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EC number: 249-854-8 | CAS number: 29797-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD 50 oral, rat, male: 3179 mg/kg,
LD 50 oral, rat, female: 2344 mg/kg (Bomhard / Bayer Ag, 1987).
There is no reliable inhalation study available.
LD 50 dermal, rat, female: >2000 mg/kg bw (Bomhard / Bayer AG, 1992) .
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline defined.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- Cited as Directive 84/449/EEC, B.1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- other: Polyethyleneglycol 400
- Doses:
- 1000, 2500, 2650 (only female rats), 3000, 3550, 5000 mg/kg bw.
- No. of animals per sex per dose:
- 1000 mg/kg= 5 animals/sex,
2500 mg/kg= 5 animals/sex,
2650 mg/kg= 5 female rats,
3000 mg/kg bw= 10 male, 15 female animals,
3550 mg/kg bw= 5 animals/sex,
5000 mg/kg bw=5 animals/sex. - Control animals:
- not specified
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 179 mg/kg bw
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 344 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD 50 for male rats was 3179 mg/kg and the LD 50 for female rats was 2344 mg/kg bw.
- Executive summary:
In an acute oral toxicity study in male and female Wistar rats, the animals received the test substance via gavage. Following doses were tested: 1000, 2500, 2650 (only female rats), 3000, 3550, 5000 mg/kg bw. The LD 50 for male rats was 3179 mg/kg and the LD 50 for female rats was 2344 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 344 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
In an acute oral toxicity study in male and female Wistar rats, the animals received the test substance via gavage. Following doses were tested: 1000, 2500, 2650 (only female rats), 3000, 3550, 5000 mg/kg bw. The LD 50 for male rats was 3179 mg/kg and the LD 50 for female rats was 2344 mg/kg bw (Bomhard / Bayer AG, 1987).
There is no reliable inhalation study available.
In an acute dermal toxicity study in male and female Wistar rats the animals were treated with the test substance for 24 h on the shaved back and flank. The dose tested was 2000 mg/kg bw. After 24 h the occlusive coverage was removed and the leftovers of test substance were washed with lukewarm water. Up to 30 minutes after application the female and male animals made sounds. After one hour all animals were symptom-free. No local skin changes were observed. During the 14 day observation-period no animal died. The LD 50 therefore was >2000 mg/kg bw (Bomhard / Bayer AG, 1992) .
Justification for classification or non-classification
The LD 50 oral for male rats was 3179 mg/kg and the LD 50 oral for female rats was 2344 mg/kg bw (Bomhard / Bayer AG, 1987). There is no reliable inhalation study available. The LD 50 dermal was >2000 mg/kg bw (Bomhard / Bayer AG, 1992) .
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification for acute toxicity is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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