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Diss Factsheets
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EC number: 223-211-1 | CAS number: 3770-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 10 - June 15, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Samples (ca 20 mL) were taken from the control and test concentration at 0 hours (fresh media), and 96 hours (old media) for analysis.
In each case, duplicate samples were taken, one for chemical analysis and one as a ‘back-up’ should further analysis be required. - Vehicle:
- yes
- Details on test solutions:
- At the start of the test, 1600.19 mg of the test substance was added to 20 L of treated mains water to give 80 mg/L test concentration. This concentration was then stirred for ca 18 hours (to allow the test substance to degrade to F6-chloride degradation products), prior to filtration through a 0.2 μm capsule filter. The control was prepared by adding treated mains water only to the control vessel.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Healthy Oncorhynchus mykiss (rainbow trout) were supplied by Northern Trout, United Kingdom, details of which are maintained in Smithers Viscient (ESG) Ltd. records.
The fish were acclimatised to the test conditions for at least 12 days prior to testing. The mortality rate of the stock batch of fish was 0% in the 7 days prior to the definitive test.
Fish were selected, at random (avoiding some unusually large fish which were not representative of the majority of the batch – not considered to impact study integrity as it is normal for more aggressive fish to grow more quickly due to aggression during feeding), from the holding tank and allocated to the test vessels at the start of each phase of testing. The fish were not fed for at least 24 hours before the start of the test and were not fed throughout the test.
The total length and wet weight of ten randomly selected fish from the stock fish were determined periodically to ensure fish were of a suitable size and weight for testing and to ensure the correct testing volumes were used so as not to exceed the recommended loading rate.
At the end of the test, the total length and wet weight of a random sub-sample of ten fish were determined, selected at random from those used in the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 86 mg/L
- Test temperature:
- 15 ± 2ºC)
- pH:
- adjusted @7 using NaOH
- Dissolved oxygen:
- Control: 96 - 103 %
Test: 93 - 98% - Nominal and measured concentrations:
- 80 mg/L (nominal)
51.6 mg/L (measured @ 0 hours)
57.4 mg/L (measured @ 96 hours) - Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 54.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: degradation product
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 54.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: degradation product
- Basis for effect:
- mortality (fish)
- Details on results:
- Based on mean measured concentration, the 96-hour LC50 value was estimated to be > 54.5 mg/L.
The corresponding NOEC value was 54.5 mg/L.
The validity criteria for control mortality (≤10%) and dissolved oxygen (≥60%) were both satisfied. The test is, therefore, considered valid. - Validity criteria fulfilled:
- yes
- Conclusions:
- Based on mean measured concentration, the 96-hour LC50 value was estimated to be > 54.5 mg/L. The corresponding NOEC value was 54.5 mg/L.
Reference
Description of key information
OECD 203: NOEC 54.5 mg/L , EC50 (96 h) > 54.5 mg/L (measured mean concentrations)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 54.5 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.