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Diss Factsheets
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EC number: 222-583-2 | CAS number: 3542-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The key information for each exposure route for acute toxicity was chosen as follows:
Acute toxicity: oral
5 studies were available to address the acute toxicity endpoint, with one from a literature source. Terrell, Y (1979) has been selected as key study.
Terrell, Y (1979). ACUTE ORAL TOXICITY OF: 1185-13 (DIOCTYLTIN DICHLORIDE), 28GO82, 28HO47, 1185-114, 1219-21 (DIMETHYLTIN DICHLORIDE), 1185-150, 1185-119 AND 1185-138 IN WEANLING SPRAGUE-DAWLEY RATS. Testing laboratory: Cannon Laboratories, Inc., P. O. Box 3627, Reading Pa., 19605. Owner company: Cincinnati Milacron, West Street, Reading, Ohio 45215. Report date: 1979-03-21.
Sarasin. G (1982). Acute Oral LD50 in the Rat. Testing laboratory: Ciba-Giegy LTD. Report no.: 820546. Owner company: KA. Report date: 1982-06-30.
Anon. (1978). Extended Acute Oral LD50 Studies of Nine Studies. Testing laboratory: Hill Top - Toxicology, Miamiville, Ohio, USA. Report no.: 77-1094-21. Owner company: Cincinnati Milacron. Report date: 1978-05-26.
Günzel. P (1968). Systemic Tolerance to a Single Application (DL50). Testing laboratory: Schering AG. Report no.: 21.979. Owner company: Crompton GmbH. Report date: 1968-08-15.
Mesch, K. A. and Kugele. T. G. (1992). Use of Organotin Stabilizers - Risk Assesment Analysis. Journal of Vinyl Technology, September 1992, Vol.14, No. 3. Report no.: Vol 14, No. 3.
Acute toxicity: dermal
No information was available for this exposure route.
Acute toxicity: inhalation
Sachsse K (1976). ACUTE INHALATION TOXICITY IN THE RAT OF TK 11339. Testing laboratory: Ciba-Giegy Limited, Basle, Switzerland. Report no.: Siss 5354. Owner company: Ciba-Giegy Limited, Basle, Switzerland. Study number: Siss 5354. Report date: 1976-05-14.
Sachsse, 1976, is the only four hour exposure study available and therefore was considered to provide a reliable result for hazard assessment purposes. Additional data is provided for supporting purposes only.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 300 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 439 mg/m³ air
Additional information
Acute Toxicity: oral
3 reliable sources of information are available for this exposure route, Sarasin, 1982; Anon, 1978, and Terrell, 1979, are all rated as reliability 2 according to the criteria of Klimisch et al, 1997, based upon their test methodologies and depth of reporting of test substance information, methodology and results.
Mesch & Kugele, 1992, was given a reliability score of 4 according to the above criteria due to insufficient reporting of methodology and result to allow for a thorough reliability assessment to be completed.
Günzel, 1968, was assigned a reliability score of 3 according to the above criteria as information on test substance, necropsy and test conditions were not reported.
The key value was chosen on a worst case basis from Terrell, 1979. This study was conducted with a similar methodology to OECD guideline 401 and EPA.OPPTS 870.1100. Testing was conducted using the gavage method with the test material suspended in corn oil, doses of 1000, 5000, 10000 and 15000 mg/kg bw (actual ingested) were used in the study. Based upon mortality observed during the study the LD50 of 3300 mg/kg bw was calculated for the registered substance.
Acute Toxicity: inhalation
Several sources of information were available for this route of exposure. Gleason, 1976 and Sachsse, 1976, were both rated as reliability 2 according to the criteria of Klimisch et al, 1997, based upon the level of reporting of methodologies and results.
The principles of the test method employed in Luy, 1976, would severely affect the reliability of the study result, and the study was therefore awarded the reliability score of 3 according to the above criteria.
Sachsse, 1976, was the only study which was conducted with a 4 hour exposure period, meaning it is the only study that could be used to assess the potential acute toxicity hazard of the registered substance by the inhalation route. Sachsse, 1976, was therefore selected as the key study. Sachsse, 1976, reported a result of 0.439 mg/l after a 4 hour exposure. A value of 439 mg/m3 is equivalent to 0.439 mg/L.
Acute toxicity: dermal
No information for this route of exposure was available.
Justification for classification or non-classification
On the basis of the available data, the substance should be classified as toxic via the inhalation route. Under the EU Dangerous Substances Directive (67/548/EEC), dioctyltin dichloride should be classified as T; R23, and under EC Regulation 1272/2008 dioctyltin dichloride should be classified as a category 2 toxin via the inhalation route H33 (Fatal if inhaled) with the signal word "Danger".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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