Registration Dossier
Registration Dossier
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EC number: 220-357-8 | CAS number: 2736-18-7
Endpoint summary
Administrative data
Description of key information
A study according to OECD 423 was performed. With a dose of 2000mg/kg bw,
administred orally to three male and three female rat there were no
deaths.
There wer no clinical signs of toxicity
All animals showed expected gains in bodyweight. No abnomalities were
noted at necropsy.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03-1998 to 04-1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- single dose 2000mg/kg
- No. of animals per sex per dose:
- 3 animals
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 100
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- no abnormalites detected
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 4,6-dichloro-1,3,5-triazin-2(1H)-on sodium salt does not show any mortality at a dose of 2000 mg/kg bw. No classification is necessary.
- Executive summary:
A study according to OECD 423 was performed.
With a dose of 2000mg/kg bw, administred orally to three male and three female rat there were no deaths.There wer no clinical signs of toxicity
All animals showed expected gains in bodyweight.
No abnomalities were noted at necropsy.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of acute toxicity – oral endpoint
well documented gideline study
Justification for classification or non-classification
A study according to OECD 423 was performed.
With a dose of 2000mg/kg bw, administred orally to three male and three
female rat there were no deaths.
There wer no clinical signs of toxicity
All animals showed expected gains in bodyweight.
No abnomalities were noted at necropsy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
