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EC number: 215-200-5 | CAS number: 1312-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
A standard respiration inhibition test according to OECD guideline 209 and GLP has been performed with the soluble Lanthanum trichloride hydrate and cerium dioxide. As the toxicity to microorganisms is likely mediated by the soluble cation, the study with lanthanum trichloride is used as a benchmark for hardly water soluble lanthanum oxide, but the value for cerium dioxide is considered more representative due to its comparable solubility properties. Cerium dioxide was not toxic to sewage treatment plant microorganisms up to the maximum concentration of 1003.8 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 304 mg/L
- EC10 or NOEC for microorganisms:
- 82 mg/L
Additional information
A standard respiration inhibition test according to OECD guideline 209 and GLP has been performed with the soluble Lanthanum trichloride hydrate (Muckle, 2009). As the toxicity to microorganisms is likely mediated by the lanthanum cation, this study is used as a benchmark for the hardly water soluble lanthanum oxide as well. The NOEC based on La3+ was 70 mgLa/L and the EC50 was 259 mg La/L, corresponding to 82 mg and 304 mg/L of La2O3. It should however be considered that the effect concentrations observed for the lanthanum ion are far above the water solubility of lanthanum oxide (69.6 micro-g/L (at pH 6.29 to 6.85))and it is therefore unlikely that lanthanum oxide will have any considerable toxicity to sewage treatment plant organisms. This is corroborated by a study with ceriumdioxide in which no significant inhibitory effect on the respiration rate of activated sludge after the incubation period of three hours at the limit test concentration of 1003.8 mg/L. Thus, the 3-hour NOEC of cerium dioxide to activated sludge microorganisms was > = 1003.8 mg/L. The 3-hour EC20, EC50 and EC80 were clearly higher than 1003.8 mg. It can therefore reasonably be assumed that lanthanum oxide will also have no significant inhibitory effects on sewage treatment plant organisms at a comparable loading rate.
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