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EC number: 212-782-2 | CAS number: 868-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- Cited as OECD Guide-line 202, part 2 (Daphnia sp., Reproduction Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Supplier: Wako Pure Chemical Ind.
Purity: 97.2 % - Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- -Test Organisms:
a) Age at Study Initiation: < 24 hours after hatching
b) Supplier/Source: Supplied from U.S. EPA Environmental Research Laboratory - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- Not applicable
- Hardness:
- 55.6 mg/L
- Test temperature:
- 19.8 - 20.4 degree C
- pH:
- 6.9-7.7
- Dissolved oxygen:
- 7.2-8.9
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- 6.25, 12.5, 25.0, 50.0 and 100 mg/L- nominal
5.44, 11.7, 24.1, 49.6, and 100 mg/L-measured - Details on test conditions:
- -Test Conditions:
a) Dilution Water Source: Dechlorination water
b) Dilution Water Chemistry: hardness= 55.6mg/L CaCO3, pH= 7.7, chlorine concentration < 0.02 mg/L
c) Exposure Vessel Type: 0.8 L-test solution in a 1 L-glass vessel
d) Nominal Concentrations (as mg/L): 6.25, 12.5, 25.0, 50.0 and 100
e) Stock solutions preparation and stability: Not used
f) Number of Replicates: 4
g) Individuals per Replicate: 10
h) Test Details: Semi-static
i) Renewal Rate of Test Water: not describe
j) Water Temperature Range: 19.8 - 20.4 degree C
k) Light Condition: 16:8 hours; light darkness cycle
l) Feeding: Daphids were fed green algae (Chlorella vulgaris); 0.1 - 0.2 mgC/day/individual - Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 24.1 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 49.6 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 90.1 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Details on results:
- see tables below: Any other information on results icl. tables
- Reported statistics and error estimates:
- -Statistical Method:
a) Data Analysis: Kruskal-Wallis test
b) Method of Calculating Mean Measured Concentrations (i.e.arithmetic mean, geometric mean, etc.): Time-weighted means - Validity criteria fulfilled:
- yes
- Conclusions:
- The 21-day NOEC for reproduction with Daphnia magna was 24.1 mg/L.
- Executive summary:
A 21-day chronic toxicity study with 2-hydroxyethyl methacrylate to daphnids (Daphnia magna) was conducted acc. OECD 202 (part 2) under semi-static conditions with 4 replicates of 10 daphnids per test concentration exposed to nominal test concentrations of 0 (control), 6.25, 12.5, 25.0, 50.0, and 100 mg/L. Water samples were measured for analytical verification of test concentrations during the exposure and the resulting time-weighted mean measured concentrations were 0 (control), 5.44, 11.7, 24.1, 49.6, and 100 mg/L. The most sensitive endpoint was reproduction and the resulting 21-day NOEC for reproduction was 24.1 mg/L.
Reference
|
Cumulative number of dead parental Daphnia |
||
Measured conc (mg/l) |
Exposure time (day) |
||
7 |
14 |
21 |
|
Control |
0 (0) |
0 (0) |
0 (0) |
5.44 |
0 (0) |
0 (0) |
0 (0) |
11.7 |
0 (0) |
0 (0) |
1 (2.5) |
24.1 |
0 (0) |
0 (0) |
0 (0) |
49.6 |
0 (0) |
0 (0) |
0 (0) |
100 |
0 (0) |
0 (0) |
0 (0) |
Time of the first brood: after 7 days
|
Mean number of juveniles produced per adult during exposure to 2-hydroxyethyl methacrylate |
||||||||||||||
Measured conc. (mg/l) |
Exposure time (day) |
||||||||||||||
0-7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
|
Control |
0 |
3.4 |
3.4 |
13.1 |
13.1 |
34.4 |
34.8 |
57.5 |
57.5 |
81.9 |
81.9 |
104 |
104 |
122 |
138 |
5.44 |
0 |
4.0 |
4.0 |
10.9 |
10.9 |
35.1 |
35.1 |
57.4 |
57.4 |
76.1 |
76.1 |
107 |
107 |
125 |
139 |
11.7 |
0 |
1.7 |
1.7 |
8.7 |
8.7 |
33.2 |
33.2 |
40.0 |
40.0 |
65.1 |
65.1 |
99.0 |
99.0 |
107 |
130 |
24.1 |
0 |
3.1 |
3.1 |
9.4 |
9.4 |
29.4 |
29.4 |
37.4 |
37.4 |
58.2 |
58.2 |
93.1 |
93.1 |
107 |
127 |
49.6 |
0 |
2.3 |
2.3 |
9.0 |
9.0 |
25.8 |
25.8 |
40.9 |
40.9 |
63.2 |
63.2 |
85.9 |
85.9 |
115 |
118 |
100 |
0 |
0 |
0 |
6.0 |
6.0 |
7.4 |
7.4 |
19.7 |
19.7 |
32.3 |
32.3 |
38.8 |
38.8 |
59.0 |
59.6 |
|
Significance test of difference between mean cumulative numbers of juveniles per adult in control and test vessels after 21 days exposure with 2-hydroxyethyl methacrylate |
|
|||||
0-7 |
8 |
9 |
10 |
11 |
12 |
||
Measured conc (mg/l) |
Vessel No. |
Mean |
SD |
Significant difference |
|||
1 |
2 |
3 |
4 |
||||
Control |
134 |
142 |
140 |
137 |
138 |
3.6 |
|
5.44 |
138 |
138 |
135 |
146 |
139 |
4.6 |
|
11.7 |
134 |
133 |
129 |
126 |
130 |
3.8 |
|
24.1 |
117 |
125 |
133 |
133 |
127 |
7.8 |
|
49.6 |
123 |
106 |
119 |
126 |
118 |
8.9 |
** |
100 |
57 |
62 |
60 |
59 |
60 |
2.0 |
|
** significantly different from control at p < 0.01
Description of key information
A long-term toxicity test with Daphnia magna exposed to 2-hydroxyethyl methacrylate and conducted under semi-static conditions, and following standard test guidelines (OECD 202, part 2), resulted in a NOEC for reproduction of 24.1 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Remarks:
- 21 d
- Effect concentration:
- 24.1 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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