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EC number: 211-687-3 | CAS number: 686-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Based on physico-chemical characteristics, particularly water solubility, octanol-water partition coefficient and vapour pressure, limited to moderate absorption by the dermal and inhalation routes are expected. Absorption following oral exposure is anticipated moderate to high.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Absorption and Distribution :
Tert-amylperoxy-2-ethylhexanoate (TAPEH) is a colourless refrigerated liquid with a molecular weight of 230.3 g/mol. The substance is only slightly soluble in water (17.6 mg/L at 20°C). The logKow of TAPEH was measured to be 4.56 at 25°C. Based on this log Kow a BCF of 3.2 L/kg was calculated. TAPEH has a low vapour pressure of 0.019 Pa at 20 °C (DSC method) and is degraded hydrolytically. The hydrolysis by-products have not been identified but are expected to be tert-amyl alcohol and 2-ethylhexanoic acid or 2-ethylhexanol. At 37 °C, the half-life time seems to decrease with the pH: t1/2 is 15.3 h at pH 9, and 29 h at pH 7. There is currently no data at pH 4 and 7 at 37 °C, but the preliminary test performed at these pH, 50°C for 5 days, has shown a strong hydrolysis. Regarding the available hydrolysis data, hydrolysis at pH 4 and 1.2 are expected, but should remain negligible during the first hours.
Oral absorption is favoured for molecular weights below 500 g/mol. Based on the high logKow of 4.56, TAPEH can be regarded as a lipophilic substance. Such a lipophilic compound may be taken up by micellular solubilisation. This mechanism may be of particular importance for TAPEH, as the substance is only slightly soluble and would otherwise be poorly absorbed. As TAPEH showed slight effects at 1000 mg/kg bw/day in a 28-day study by oral, it can be assumed that absorption across the gastrointestinal tract epithelium occurs, even if the observed effects were non-adverse.
Based on the low vapour pressure of 0.019 Pa at 25 °C, inhalation exposure is not likely. Nevertheless, if the substance reaches the lung, TAPEH may be absorbed by micellular solubilisation (see above). The low water solubility may enhance penetration to the lower respiratory tract. Together, this indicates low systemic availability after inhalation and if bioavailable, toxic effects via this route of administration will occur only at very high concentrations.
Similarly, based on physical-chemical properties of TAPEH, the substance is not likely to penetrate skin to a large extent as the high logKow and the low water solubility do not favour dermal penetration. Between water solubility of 1-100 mg/l absorption is anticipated to be low to moderate. For substances with a log Kow between 4 and 6, the rate of penetration is limited by the rate of transfer between the stratum corneum and the epidermis. Only the uptake into the stratum corneum should be high. Furthermore, TAPEH is not irritating to rabbit skin. Applied to the skin of guinea pigs, sensitising effects were observed, indicating that at least small amounts of the substance will become available in the body. However, the effects noted might also be linked to reaction by-products between TAPEH and molecules present in the skin.
When reaching the body, TAPEH may be distributed into cells due to its lipophilic properties and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues. Based on its relatively high BCF value TAPEH may also be considered to bioaccumulate in the human body. However, it is suspected that TAPEH does not reach the blood without hydrolysing (enzymatically or hydrolytically) to its degradation products which will have lower BCF (tert-amyl acohol and 2-ethylhexanoic acid or 2-ethylhexanol).
Metabolism:
Based on the structure of the molecule and its nature, metabolism to more toxic metabolites can not completely be excluded in the human body. This is in compliance with the results obtained in the one Ames test showing only positive effects with S9 activating metabolising system.
Excretion:
As discussed above TAPEH is expected to be hydrolysed enzymatically in products having lowest molecular weight, allowing them to be excreted via the urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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