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EC number: 211-189-6 | CAS number: 632-99-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Long term toxicity to Heteropneustes fossilis (Catfish) study was carried out for 60 days.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride
- Common name: Fuschin basic
- Molecular formula: C20H19N3.HCl
- Molecular weight: 337.852
- Smiles notation: C(\c1cc(c(N)cc1)C)(c1ccc(N)cc1)=C1/C=CC(=N)C=C1.Cl
- InChl: 1S/C20H19N3.ClH/c1-13-12-16(6-11-19(13)23)20(14-2-7-17(21)8-3-14)15-4-9-18(22)10-5-15;/h2-12,21H,22-23H2,1H3;1H/b20-14-,21-17?;
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Details on sampling:
- - Concentrations: Test chemical concentration used for the study were 6.24 mg/l (for 96 h), 3.12 mg/l (for 10-20 days) and 1.56 mg/l (for 10 days), respectively.
- Vehicle:
- not specified
- Test organisms (species):
- other: Heteropneustes fossilis
- Details on test organisms:
- TEST ORGANISM
- Common name: Catfish - Test type:
- not specified
- Water media type:
- brackish water
- Total exposure duration:
- 60 d
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 60 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.12 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: No significant difference in the serum calcium and protein levels was observed from that of controls.
- Details on results:
- Exposure of the catfish to acute (6.24 ppm) level of fuchsin basic for 96 h and to sub-acute (3.12 ppm) for short (10-20 days) and sub-lethal (1.56 ppm) for 10 days, resulted in significant decrease in serum calcium and protein levels. However, long term (30-60 days) exposure of test organism to both 3.12 mg/l and 1.56 mg/l levels, did not produced significant difference in the serum calcium and protein levels from that of controls.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- For chemical, (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride, as no significant difference in the serum calcium and protein levels was observed from that of controls, the 60 days NOEC value was determined to be 3.12 mg/l, respectively.
- Executive summary:
Long term toxicity to Heteropneustes fossilis (Catfish) study was carried out for 60 days.The study was based on the effects of the test compound (4-(4-aminophenyl)(4-iminocyclohexa -2,5 -dienylidene)methyl)-2-methylaniline hydrochloride (CAS no. 632-99-5) on Heteropneustes fossilis in a brackish water system. Heteropneustes fossilis (Catfish) was used as a test organism. Test chemical concentration used for the study were 6.24 mg/l (for 96 h), 3.12 mg/l (for 10-20 days) and 1.56 mg/l (for 10 days), respectively. As no significant differences in the serum calcium and protein levels was observed from that of controls, the 60 days NOEC value was determined to be 3.12 mg/l, respectively.
Reference
Description of key information
Long term toxicity to Heteropneustes fossilis (Catfish) study was carried out for 60 days(American chemical society, 2017). The study was based on the effects of the test compound (4-(4-aminophenyl)(4-iminocyclohexa -2,5 -dienylidene)methyl)-2-methylaniline hydrochloride (CAS no. 632-99-5) on Heteropneustes fossilis in a brackish water system. Heteropneustes fossilis (Catfish) was used as a test organism. Test chemical concentration used for the study were 6.24 mg/l (for 96 h), 3.12 mg/l (for 10-20 days) and 1.56 mg/l (for 10 days), respectively. As no significant differences in the serum calcium and protein levels was observed from that of controls, the 60 days NOEC value was determined to be 3.12 mg/l, respectively.
Key value for chemical safety assessment
Additional information
Long term toxicity to Heteropneustes fossilis (Catfish) study was carried out for 60 days(American chemical society, 2017). The study was based on the effects of the test compound (4-(4-aminophenyl)(4-iminocyclohexa -2,5 -dienylidene)methyl)-2-methylaniline hydrochloride (CAS no. 632-99-5) on Heteropneustes fossilis in a brackish water system. Heteropneustes fossilis (Catfish) was used as a test organism. Test chemical concentration used for the study were 6.24 mg/l (for 96 h), 3.12 mg/l (for 10-20 days) and 1.56 mg/l (for 10 days), respectively. As no significant differences in the serum calcium and protein levels was observed from that of controls, the 60 days NOEC value was determined to be 3.12 mg/l, respectively.
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