Registration Dossier
Registration Dossier
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EC number: 209-136-7 | CAS number: 556-67-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
93 d NOEC ≥4.4 µg/l based on embryo viability, hatching success, larval survival and growth, Oncorhynchus mykiss, measured, Springborn Laboratories, 1991b.
Key value for chemical safety assessment
Additional information
A 93-day chronic NOEC of ≥4.4 µg/l has been determined for the effects of the test substance on embryo viability, hatching success, larval survival and growth of early life stages of Oncorhynchus mykiss (Springborn Laboratories 1991b). No effects were seen at the highest concentration tested. Therefore, the overall long-term NOEC for fish is considered to be ≥4.4 µg/l.
However, to better define the potential NOEC, modelling (Mackay et al., 2015) to estimate fish critical body burden (CBB) levels and compare those CBB levels to those associated with a narcotic mode of action (MOA), under which the D4 and other volatile methyl siloxanes materials are proposed to operate (Redman et al., 2012, Mackay et al., 2015) was conducted. These results indicate that D4 dose levels up to 12 µg/l could have been successfully used in the D4 93-day trout ELS study without adverse effect.
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