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Diss Factsheets
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EC number: 206-076-3 | CAS number: 299-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- ca. 6.28
- Temp.:
- 25 °C
- No.:
- #2
- pKa:
- ca. 8.13
- Temp.:
- 25 °C
- Conclusions:
- Results are presented below for the two pKa values determined by potentiometric titration following the OCED test method 112 (12-05-81) protocol.
pKa 1 = 6.28
pKa 2 = 8.13
Results are presented below for the two pKa values determined by potentiometric titration following the OCED test method 112 (12-05-81) protocol.
pKa 1 = 6.28
pKa 2 = 8.13
pKa values are plotted against sample weight and extrapolated back to zero weight to determine the ideal pKa values. All of the individual pKa measurements met the test guideline for suggested repeatability quality criteria of ± 0.1 pKa units of the mean.
Reference
The electrode was calibrated with pH 4, 7, and 10 traceable buffer solutions and a calibration slope of 99.0% was obtained. The room temperature was recorded as 25°C.
The iron gluconate test material was determined to be acidic and subsequently titrated with 0.1 N NaOH to produce titration curves of pH versus volume of titrant added. Table 1 provides a summary of the titration data. The pKa values acquired for each endpoint were plotted on separate graphs against sample weight and extrapolated back to zero weight to determine the ideal pKa value.
Table 1. Summary of Titration Results for Iron Gluconate
Weighing Number | Wt. of test substance (g) | EnpointNumber | Endpoint Vol (mL) | Half-Point pH (pKa) | Half-pointVol (mL) | Deviation from Mean pKa |
1 | 0.0764 | 1 | 1.47 | 6.21 | 0.74 | -0.02 |
2 | 3.24 | 8.11 | 2.36 | -0.01 | ||
2 | 0.1402 | 1 | 1.44 | 6.24 | 0.72 | -0.06 |
2 | 5.23 | 8.12 | 3.33 | -0.01 | ||
3 | 0.2493 | 1 | 1.49 | 6.11 | 0.74 | 0.08 |
2 | 9.18 | 8.10 | 5.33 | 0.01 |
Description of key information
Results are presented below for the two pKa values determined by potentiometric titration following the OCED test method 112 (12-05-81) protocol.
pKa 1 = 6.28
pKa 2 = 8.13
pKa values are plotted against sample weight and extrapolated back to zero weight to determine the ideal pKa values. All of the individual pKa measurements met the test guideline for suggested repeatability quality criteria of ± 0.1 pKa units of the mean.
Key value for chemical safety assessment
- pKa at 20°C:
- 6.28
Additional information
The above value was recorded at 25*C
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