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Diss Factsheets
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EC number: 205-613-9 | CAS number: 144-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There is one study with sufficient reliability with oral administration in rats. Acute toxicity oral in rat was reported as LD50 600 mg/kg bw.
According to this result a classification for acute toxicity oral in Category 4 based on GHS criteria is recommended.
Further one study with oral administration, two studies with intraperitoneal administration, two studies with intravenous administration and four subcutaneous administration have no sufficient reliability and are therefore ignored.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- This method has a similar structure to the acute toxic class method (OECD 423), which was adopted years later in 1996.
- Principles of method if other than guideline:
- The development of a method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is described. This method has a similar structure to the acute toxic class method (OECD 423), which was adopted years later in 1996.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Animals were treated with substances after at least 5 days of adaptation.
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- In the initial investigations the range of doses producing the toxic effects is established. Based on these results, further specific doses are administered to calculate an LD50.
- Doses:
- first part of investigation: 10/100/1000 mg/kg bw, second part of investigation: 100/140/225/370/600/1000 mg/kg bw.
- No. of animals per sex per dose:
- first part of investigation: 3 animals per dose; second part of investigation: each of the proposed doses was given to groups consisting of one animal, two animals, three animals and five animals.
- Control animals:
- not specified
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: dose group consisting of 5 animals
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 650 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: dose group consisting of 3 animals
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: dose group consisting of 2 animals
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 770 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: dose group consisting of 1 animal
- Conclusions:
- Classification category 4 based on GHS criteria.
- Executive summary:
- A method for the investigation of the acute toxicity of chemical substances, with an estimation on the LD50, is described.
This approach is a stepwise procedure with the use of 3 male rats in the first step and 1/2/3/5 male rats in the second step. Mortality and/or the moribund status of the animals was observed. This method has a similar structure to the acute toxic class method (OECD 423), which was adopted years later in 1996. The acute toxicity oral in rats was reported as LD50 600 mg/kg bw in male rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 600 mg/kg bw
- Quality of whole database:
- Study period before the adoption of guideline OECD 423, but similar stucture of method.
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.