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Diss Factsheets
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EC number: 200-279-0 | CAS number: 56-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 of quinidine for rats after oral application is 263 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is not done according to OECD guideline, but it is a well documented study.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In this study the oral acute toxicity of quinidine hydrochloride was assessed in 10-14 weeks old SPF-Sprague-Dawley rats (weighing 160 to 220 g). For the studies ten animals per dose, five males and five females, were used. For the oral application the substance was solved in 1% methylcellulose. 20 ml/kg bw of the compound was administered by oral gavage. The animals were closely observed for a total of 7 observation days provided the rats did not die earlier. The LD50 with a confidence interval of 95% was calculated with the probit analysis of Finney (1962) as well as Fink and Hund (1965).
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Strain: SPF-Sprague-Dawley rats (50% female, 50% male)- Age at study initiation: 10-14 weeks- Weight at study initiation: 160-220g
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1 % methylcellulose
- Details on oral exposure:
- VEHICLE- Concentration: 1%- Amount of vehicle (if gavage): 20 ml/kg bw
- No. of animals per sex per dose:
- 10 rats per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: The animals were closely observed for a total of 7 observation days provided the rats did not die earlier.
- Statistics:
- The LD50 with a confidence interval of 95% was calculated with the probit analysis of Finney (1962) as well as Fink and Hund (1965).
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 263 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 234 - <= 295
- Interpretation of results:
- toxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The LD50 of quinidine hydrochloride for Sprague-Dawley rats is 263 mg/kg bw after oral application.
- Executive summary:
In the study published by Dietmann et al., 1977 the oral toxicity of quinidine hydrochloride was tested on Sprague-Dawley rats. From this study it is shown, that the LD50 of quinidine hydrochloride is 263 mg/kg bw. According to this, the LD50 of quinidine is 236 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 236 mg/kg bw
- Quality of whole database:
- There are no details on the method available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute toxicity of quinidine was tested on rats via oral route. From the study it is shown, that the LD50 is 236 mg/kg bw. It is considered as toxic if swallowed according to EU criteria.
Justification for classification or non-classification
The LD50 of quinidine for rats after oral application is 236 mg/kg bw. According to CLP 1272/2008 criteria for oral application, LD50 > 50 mg/kg bw and < 300 mg/kg bw, quinidine is considered as toxic if swallowed and has to be classified in category 3.
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