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EC number: 692-614-6 | CAS number: 5660-53-7
Table 184.108.40.206: Individual grading of eye reactions (scores)
* mean values calculated as the mean scores of readings at 24, 48 and 72 hours.
** presence of ulcer
An acute eye irritation study was performed with 2-isobutyl-2-methyl-1,3-dioxolane-4-methanol in New Zealand White rabbits according to the OECD 405 Guideline and in compliance with the GLP.
Three male rabbits were employed. The test substance (0.1 mL) was applied undiluted into the left eye of each rabbit. The contralateral eye was used as control. The eyes of the rabbits were then evaluated at various times after application (1, 24, 48 and 72 hours for the first animal tested and 1, 24 and 48 hours for the second and third animals tested) for signs of ocular reactions in the iris, cornea and conjunctivae. Irritation was scored according to the Draize method.
No systemic toxicity or abnormality in body weight gain was detected during the observation period.
In the first animal tested, conjunctivae redness, chemosis and iritis were observed during evaluation of 1, 24 and 48 hours. Opacity was observed at 1 hour of evaluation until 24 hours. On day 3, all ocular effects were reverted. In the second and third animals tested, corneal opacity, iritis, chemosis and conjunctival redness were observed during evaluations of 1, 24 and 48 hours. At 48 hours, corneal ulceration, considered irreversible lesion, was observed and the test was terminated.
In conclusion, 2-isobutyl-2-methyl-1,3-dioxolane-4-methanol requires classification as eye corrosive (Category 1; irreversible effects on the eye) according to the Regulation (EC) 1272/2008 (CLP) and GHS UN criteria.
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