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Description of key information

Hydrolysis

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Additional information

Hydrolysis

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C.Test substance was added in the test water of pH 4, pH 7 and pH 9 to be the test concentration of about 0.05 mg/L. These test solutions were shaked for 5 days at 50 degree C. After that, the test chemical concentration of each test water was measured and compared with the initial concentration. Analytical method involve the use of HPLC. L-column ODS (15 cm x 4.6 mm I.D.) was used as a column for the study. Although the half-life value of test chemical was not known, but the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50⁰C and at pH 4, 7 and 9, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

For the test chemical, the half-life of the test chemical was determined. The study was performed at a temperature of 50⁰C. Test chemical was reported to be hydrolytically stable with a corresponding half-life value of> 1 yrat a temperature of 50⁰C, respectively. Thus, based on the half-life value, it is concluded that the test chemical is not hydrolysable in water.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.