Registration Dossier
Registration Dossier
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EC number: 210-734-5 | CAS number: 622-40-2
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.2 L/kg ww
Additional information
The partition coefficient octanol/water of 2 -morpholinoethanol was estimated to be -1.32 using the KOWWIN program v1.68 of EPI Suite v4.11 (BASF SE, 2016). In accordance with column 2 of REACH Annex IX, the study need not be conducted since the substance has a log Kow less or equal than 3.
However, in order to assess the bioaccumulation potential of the test substance, the BCF was calculated using the BCFBAF Program v3.01 of EPI Suite v4.11 (BASF SE, 2016) as well as the BCF base line model v02.09 of OASIS Catalogic v5.11.17 (BASF SE, 2015):
Estimated BCF values:
- BCFBAF v3.01 (EPISuite v4.11): 3.2 L/kg; substance within applicability domain (AD)
- BCF base line model v02.09 (OASIS Catalogic v5.11.17): 2.3 L/kg (incl. biotransformation) / 9.3 L/kg (without biotransformation); substance within AD
Based on these results it can be concluded that significant accumulation in organisms is not to be expected.
QSAR-disclaimer:
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 4-Morpholineethanol (Q)SAR results were used for aquatic bioaccumulation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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