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EC number: 401-300-8 | CAS number: -
In order to assess the test article's potential to cause clastogenic effects on somatic interphase cells in vivo, female and male Chinese hamsters were treated by gavage with the test substance once daily on two consecutive days at dose levels of 1250, 2500 or 5000 mg/kg body weight. A control group was treated according to the same dosing scheme with the vehicle alone (0.5% CMC). The animals were sacrificed 24 h after the second application and smears from the bone marrow were made. The bone marrow smears from animals treated with the various doses showed no significant increase from the control. The incidence of bone marrow cells with anomalies of nuclei corresponds to the frequency observed in the control group. By contrast, a "positive control" experiment with cyclophosphamide (128 mg/kg) yielded 8.08% cells with anomalies of nuclei. This is significantly different from the controls (0.08%) treated with the vehicle alone. It is concluded that under the conditions of this experiment, no evidence of mutagenic effects was obtained in Chinese hamsters treated with the test substance.
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