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EC number: 401-300-8 | CAS number: -
The test article was investigated for its clastogenic potential in an in vivo nucleus anomaly test performed in Chinese hamsters similar to OECD TG 474 (Ciba-Geigy, 850047, 1985). The test substance was administered by gavage in daily doses of 1250, 2500 or 5000 mg/kg on each of two consecutive days. The animals were sacrificed 24 h after the second application and smears from the bone marrow were made. Treatment with the test article with the various doses did not result in significant increases in nucleus anomalies when compared to the control. By contrast, a "positive control" experiment with cyclophosphamide (128 mg/kg) yielded 8.08% cells with anomalies of nuclei. This is significantly different from the controls (0.08%) treated with the vehicle (0.5% CMC) alone. It is concluded that under the conditions of this experiment, no evidence of mutagenic effects was obtained in Chinese hamsters treated with the test substance.
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the purpose of classification under Directive 67/548/EEC. Based on the present data, classification for genotoxicity is not warranted under Directive 67/548/EEC.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. Based on the present data, classification for genotoxicity is not warranted under Regulation (EC) No.1272/2008.
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