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EC number: 401-300-8 | CAS number: -
In a GLP-compliant skin irritation study performed according to OECD guideline 404, three New Zealand White rabbits were treated occlusively with 0.5 g of the test article. The test article was applied with a moistened gauze patch to the clipped flank of the animals and held in place for 4 hours by an adhesive tape. Control patches were applied to the contralateral flank. The skin reactions were evaluated 1, 24, 48, and 72 hours after removing the gauze patches and animals were checked daily for signs of systemic toxicity. Under the experimental conditions employed the test article induced minimal to mild erythema and edema reactions well below the threshold of significance. All signs of irritations disappeared within 72 days the latest. The test article is therefore classified as non irritating.
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