Registration Dossier
Registration Dossier
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EC number: 208-212-7 | CAS number: 515-84-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A published study on lipid metabolism after repeated subcutaneous dosing of Ethyl trichloroacetate was available; the study was not meant for regulatory purpose and did not follow test guidelines, therefore it was taken up for completeness, but disregarded for classification.
Rats maintained on a choline deficient diet and
treated with subcutaneous doses of ethyl trichloroacetate responded by
increasing plasma β-lipoprotein and plasma triglyceride levels while
excess triglyceride was being removed from the liver. There was a
transient depression in plasma phospholipid at the beginning of the
treatment. Continued administration of ethyl trichloroacetate raised
plasma triglyceride in choline depleted rats and raised hepatic
phospholipid concentration in both choline deficient and supplemented
rats.
It is suggested that the lipotropic action of ethyl trichloroacetate
occurs through hepatic triglyceride being removed by the altered plasma
lipids and not by inhibition of hepatic triglyceride synthesis.
Justification for classification or non-classification
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