Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Only one study on animals with reliability 3 was available (Goldberg, 1963). This study showed that guaiacol is not a skin sensitizer and was considered as a weight of evidence one regarding human data (Kligman, 1978). In Kligman, 1978 study which is considered as a key study, no signs of sensitization were observed on 25 healthy adult volunteers after a patch test with gaiacol.

Based on these studies, gaiacol is not considered as sensitizing.

Migrated from Short description of key information:
Gaiacol is considered as not sensitizing (published data) based on one animal and one human study.

Justification for classification or non-classification