Registration Dossier
Registration Dossier
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EC number: 201-964-7 | CAS number: 90-05-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin sensitisation study does not need to be conducted because adequate data from an in vivo skin sensitisation study are available
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Only one study on animals with reliability 3 was available (Goldberg, 1963). This study showed that guaiacol is not a skin sensitizer and was considered as a weight of evidence one regarding human data (Kligman, 1978). In Kligman, 1978 study which is considered as a key study, no signs of sensitization were observed on 25 healthy adult volunteers after a patch test with gaiacol.
Based on these studies, gaiacol is not considered as sensitizing.
Justification for classification or non-classification
Gaiacol is considered as not sensitizing (published data) based on one animal and one human study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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