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Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vitro
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
an in vitro skin sensitisation study does not need to be conducted because adequate data from an in vivo skin sensitisation study are available
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Only one study on animals with reliability 3 was available (Goldberg, 1963). This study showed that guaiacol is not a skin sensitizer and was considered as a weight of evidence one regarding human data (Kligman, 1978). In Kligman, 1978 study which is considered as a key study, no signs of sensitization were observed on 25 healthy adult volunteers after a patch test with gaiacol.

Based on these studies, gaiacol is not considered as sensitizing.


Justification for classification or non-classification

Gaiacol is considered as not sensitizing (published data) based on one animal and one human study.