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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No details were reported on the protocol, the animals and the purity of the test substance.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Kirwin C.J., Galvin J.B.
Year:
1982
Bibliographic source:
Journal Patty's Industrial Hygiene and Toxicology. 4th ed. New York: John Wiley Sons, 448-449, 481-485. Ethers: chapter 8.
Reference Type:
publication
Title:
Monographs on fragrance raw materials
Author:
Opdyke DL, Letizia C.
Year:
1982
Bibliographic source:
Food Chem Toxicol, 20, 697-701.

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Guaiacol
EC Number:
201-964-7
EC Name:
Guaiacol
Cas Number:
90-05-1
Molecular formula:
C7H8O2
IUPAC Name:
Phenol
Details on test material:
The origin of the test substance was not reported and its purity was unknown.

Test animals

Species:
other: rat, rabbit, guinea pig, pigeon
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
No data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
170 mg/kg bw
Remarks on result:
other: by i.v. in mouse
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
0.2 other: g
Remarks on result:
other: by s.c. in pigeon
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
2.5 other: g
Remarks on result:
other: by s.c. in rabbit
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
900 mg/kg bw
Remarks on result:
other: by s.c. in guinea pig and rat

Applicant's summary and conclusion