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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No details were reported on the protocol, the animals and the purity of the test substance.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Kirwin C.J., Galvin J.B.
Year:
1982
Bibliographic source:
Journal Patty's Industrial Hygiene and Toxicology. 4th ed. New York: John Wiley Sons, 448-449, 481-485. Ethers: chapter 8.
Reference Type:
publication
Title:
Monographs on fragrance raw materials
Author:
Opdyke DL, Letizia C.
Year:
1982
Bibliographic source:
Food Chem Toxicol, 20, 697-701.

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
The origin of the test substance was not reported and its purity was unknown.

Test animals

Species:
other: rat, rabbit, guinea pig, pigeon
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
No data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
170 mg/kg bw
Remarks on result:
other: by i.v. in mouse
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
0.2 other: g
Remarks on result:
other: by s.c. in pigeon
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
2.5 other: g
Remarks on result:
other: by s.c. in rabbit
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
900 mg/kg bw
Remarks on result:
other: by s.c. in guinea pig and rat

Applicant's summary and conclusion