Registration Dossier
Registration Dossier
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EC number: 201-964-7 | CAS number: 90-05-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No details were reported on the protocol, the animals and the purity of the test substance.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Kirwin C.J., Galvin J.B.
- Year:
- 1 982
- Bibliographic source:
- Journal Patty's Industrial Hygiene and Toxicology. 4th ed. New York: John Wiley Sons, 448-449, 481-485. Ethers: chapter 8.
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials
- Author:
- Opdyke DL, Letizia C.
- Year:
- 1 982
- Bibliographic source:
- Food Chem Toxicol, 20, 697-701.
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Guaiacol
- EC Number:
- 201-964-7
- EC Name:
- Guaiacol
- Cas Number:
- 90-05-1
- Molecular formula:
- C7H8O2
- IUPAC Name:
- Phenol
- Details on test material:
- The origin of the test substance was not reported and its purity was unknown.
Constituent 1
Test animals
- Species:
- other: rat, rabbit, guinea pig, pigeon
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Doses:
- No data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 170 mg/kg bw
- Remarks on result:
- other: by i.v. in mouse
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 0.2 other: g
- Remarks on result:
- other: by s.c. in pigeon
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 2.5 other: g
- Remarks on result:
- other: by s.c. in rabbit
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 900 mg/kg bw
- Remarks on result:
- other: by s.c. in guinea pig and rat
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
