Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Experimental determination according to now standardized method with pure substance.
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
not specified
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
1.36 - 1.57
Temp.:
30 °C
Remarks on result:
other: no data on pH available
Details on results:
Lipophilic properties are quantatively characterized by Rm values obtained from reversed-phase TLC and by log k values obtained from reversed-phase HPLC experiments.
Rm and Log k are proportional to Log P.

After calculation of Rm and log k, a regression analysis allows to determine Rm° and log k° by extrapolation to a 0% methanol concentration.

Results of measurements obtained were :
Rm° = 1.25 (s.d.=0.09)
Log k° = 1.02 (s.d.=0.05)

This allows to calculate Log P according to the regression equations obtained from the other compounds :

Log P = (Rm° + 0.2426)/1.0988 = 1.36

Log P = (Log k° + 0.3112)/0.8478 = 1.57

No information on pH

Description of key information

The range of log Kow  was from 1.32 to 2.53.
Guaiacol has a low potential of bioaccumulation.

Key value for chemical safety assessment

at the temperature of:
20 °C

Additional information

Nine publications report logKow values on guaiacol. These range from 1.32 to 2.53

One of them was chosen as a key study (Butte et al., 1982), since performed according to the OECD guideline 117 (HPLC method), with a range of results from 1.36 to 1.57 at 30°C.