Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Short description of key information:
In the bacterial mutation test (Ames test), up to 5000 µg/plate no signs of toxicity and no mutagenic activity were observed.
In the chromosomal aberration test with human lymphocytes, no increases in the proportion of metaphase figures containing aberrations occurred.
In the third in vitro test, the mouse lymphoma assay, TN-105 did not reveal a mutagenic potential.
In summary, the in vitro battery of mutagenicity showed a statistically clear negative outcome.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification