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EC number: 430-610-6 | CAS number: 226996-19-6
Maximum concentration not causing irritating effects in preliminary test: 60 %Signs of irritation during induction:Intradermal injection: Necrosis was recorded in all animalsreceiving Freund's complete Adjuvant. Most animals displayedslight irritation, with 2/10 showing well-defined irritationand 1/10 animal showing moderate irritation. Slightirritation was seen in control animals.Topical application: 5/10 animals showed slight erythema,5/10 showed well-defined erythema. Slight (4/5 animals) towell defined (1/5 animals) erythema was seen in the controlanimals.Evidence of sensitisation of each challenge concentration:At first challenge at 60 % w/v, the sample stuck to the skincausing mechanical damage at bandage removal for all controland test animals. No reactions were observed at 30 % w/v inAlembicol D for any control or test animals.Second challenge: There were no dermal responses in any ofthe control or test animals.Other observations:One test animal was sacrificed for humane reasons followingthe first challenge. Ulceration had been observed around thesite of injection prior to the challenge application. Thisulceration persisted and the animal became thin with anungroomed appearance. No abnormalities were observed duringpost-mortem examination.No signs of toxicity or ill-health were observed for theremaining animals.
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