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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2001
Report Date:
2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 92/69/EWG, B.3; OECD 402 (1987)
GLP compliance:
yes
Test type:
other: OECD 402
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rat, Sprague-Dawley HSD:CD

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: 1 % aqueous methylcellulose
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
There were no deaths and no systemic response to treatment
following a single application.

No change in bodyweight was recorded for one female on Day 8
with a slight loss in bodyweight in the same animal on

Day 15. Low bodyweight gains were recorded for one male and
three females on Day 8 and for three females on day 15. All
other animals were considered to have achieved satisfactory
bodyweight gains throughout the study.
Gross pathology:
Effects on organs:
No abnormalities were revealed at study termination.
Other findings:
Signs of toxicity (local):
There were no dermal reactions to treatment in any animal
throughout the study.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Not classified