Registration Dossier
Registration Dossier
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EC number: 432-090-6 | CAS number: -
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Commission Directive 92/69/EEC Method B12 OECD Guidelines for testing of chemicals no. 474.
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test animals
- Species:
- other: Albino Crl:CD-1 (ICR) BR mice
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Arachis Oil
- No. of animals per sex per dose:
- Male: 0 mg/kg; No. of animals: 7; Sacrifice time: 48 hours
Male: 0 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Male: 50 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Male: 100 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Male: 200 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Male: 200 mg/kg; No. of animals: 7; Sacrifice time: 48 hours
Results and discussion
Test results
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity: The highest dose of 200mg/kg/day caused no deaths. However hunched posture and lethargy were seen in animals dosed at and above 100mg/kg/day at both the 24 and 48 hour sampling times where applicable.
- Additional information on results:
- Observations:
The test material did not cause a significant increase in
the frequency of micronuclei in the polychromatic
erythrocytes of the mice treated in this study.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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