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EC number: 434-430-9 | CAS number: -
The dermal LD50 value of EA-3098 in Wistar rats was established to exceed 2000 mg/kg body weight.
Assessment of the acute dermal toxicity of EA-3098 in the rat was determined according to the following methods:
-OECD No. 402 (1987) "Acute Dermal Toxicity"
-EC Council directive 67/548/EEC, Annex V, B.3 (1992) "Acute Toxicity (Dermal)2
-EPA OPPTS. 870.1200 (1998), "Acute Dermal Toxicity"
-JMAFF Guidelines (2000), including the most recent revisions.
EA-3098 was administered to five Wistar rats of each sex by a single dermal application at 2000 mg/kg body weight for 24 hours. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice (Day 15).
One male was found dead on Day 2 of treatment.
Flat or hunched posture, ptosis and/or chromodacryorrhoea were noted in all males and some females on Day 1 and/or Day 2.
Scales and/or scabs were seen in the treated skin-area of all females and one male during the observation period.
The body weight gain of the surviving animals during the observation period was within the range expected for rats used in this type of study.
No test substance related abnormalities were found at macroscopic post mortem examination of the animals.
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