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EC number: 436-710-6 | CAS number: 756-13-8
A Reproductive/Developmental screening study was conducted on 756-13-8. This study followed the OECD 421 Guidelines. Animals were dosed via inhalation at doses of 0, 300, 1000 and 3000 ppm. No differences were seen between the control animals and the test animals at any dose levels. Endpoints include number of litters, number of pups per litter, pup weight, reproductive organ weight or macroscopic changes. The NOAEL for parental toxicity, fertility and developmental toxicity was at least 3000 ppm.
An Inhalation Prenatal Developmental study was conducted according to OECD Protocol 414. Animals were dosed via inhalation to concentrations of 0, 100, 300 and 3000 ppm. There were no test substance-related clinical findings or effects on mean maternal body weight, body weight gains, or food consumption observed at any exposure level. In addition, there were no test substance-related effects on embryo/fetal development at any dosage level. Based on the results of this study, a dosage level of 3000 ppm, the highest exposure level evaluated, was considered to be the no-observed-adverse-effect-level (NOAEL) for maternal toxicity and embryo/fetal development when MTDID 5789 was administered via whole body inhalation to bred Crl:CD(SD) rats.
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