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EC number: 436-710-6 | CAS number: 756-13-8
The study report concludes that the NOEC based on frond number is 17.7 mg/L. Average specific growth rates were not presented in the study report. Growth rates were calculated by the sponsor after the report was issued, using methods described in OECD TG211, Lemna sp. Growth Inhabition Test (adopted 23 March 2006) using Microsoft Excel. Reanalysis of the data using Student's t-test indicates that the 16% reduction in total number of fronds relative to controls on day seven is statistically significant (P=0.03). Comparison of average specific growth rates on day seven shows a 7.4% reduction by day 7 (P=0.03). The reported NOEC is therefore not valid.
Tables 4 & 5, Plant biomass and average specific growth rate data from study report.
The 7-day toxicity of CAS# 756-13-8 to Lemna gibba was studied under static conditions. Lemna gibba was exposed to a negative control and CAS# 756-13-8 at a nominal concentration of 500 mg/L for seven days. Dissolved CAS# 756-13-8 hydrolyzes completely with a half-life of 2.5 minutes to perfluoropropionic acid (PFPA) and a volatile hydrofluorocarbon (heptafluoropropane). PFPA concentration was monitored by HPLC-MS. The measured exposure concentration of PFPA was 17.7 mg/L. The 7-day EC50 based on average specific growth rate were >17.7 mg/L as PFPA. The 7-day NOEC based on average specific growth rate could not be calculated because there was statistically significant inhibition at the only concentration tested.
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with algae.
Test Organism Age: nine days
Test Type: Static
EC50: >17.7 mg/L as PFPA 95% C.I.: not applicable
NOEL: not calculated Probit Slope: not applicable
Endpoint(s) Effected: Average specific growth rate
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