Registration Dossier
Registration Dossier
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EC number: 410-290-4 | CAS number: 80693-00-1 ADK STAB PEP-36
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 February 1988 to 20 July 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study in accordance with internationally recognised guideline
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,9-bis(2,6-bis(1,1-dimethylethyl)-4-methylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- IUPAC Name:
- 3,9-bis(2,6-bis(1,1-dimethylethyl)-4-methylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Remarks:
- Eau (0,5 ml)
- Controls:
- no
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0
Any other information on results incl. tables
Animal |
Sex |
Observation interval |
|||
30-60 min |
24 h |
48 h |
72 h |
||
Erythema |
|||||
1 |
M |
0 |
0 |
0 |
0 |
2 |
M |
0 |
0 |
0 |
0 |
3 |
M |
0 |
0 |
0 |
0 |
4 |
F |
0 |
0 |
0 |
0 |
5 |
F |
0 |
0 |
0 |
0 |
6 |
F |
0 |
0 |
0 |
0 |
Edema |
|||||
1 |
M |
0 |
0 |
0 |
0 |
2 |
M |
0 |
0 |
0 |
0 |
3 |
M |
0 |
0 |
0 |
0 |
4 |
F |
0 |
0 |
0 |
0 |
5 |
F |
0 |
0 |
0 |
0 |
6 |
F |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- No mortality occurred during the study. There was no erythema, edema or any other dermal effects noted at any time during the study. Based
on the results of the study, Phosphorous acid, neopentanetetrayl bis (2,6-di-tert-butyl-4-methylphenyl) ester is not a dermal irritant .
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