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EC number: 214-244-2 | CAS number: 1117-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- October 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study, tested with the source substance propane-1,2-diyl diacetate (CAS 623-84-7). In accordance to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Propane-1,2-diyl diacetate
- EC Number:
- 210-817-6
- EC Name:
- Propane-1,2-diyl diacetate
- Cas Number:
- 623-84-7
- Molecular formula:
- C7H12O4
- IUPAC Name:
- propane-1,2-diyl diacetate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Three young adult, female, New Zealand White rabbits obtained from Ranch Rabbits, Crawley were used for the study.
At the start of the study the rabbits weighed between 4.00 and 4.45 kg and were aged between 11 and 20 weeks. They were acclimatised to the laboratory environment for at least 3 days and were examined for signs of ill health or eye defects shortly before the study started.
The animals were housed individually in grid floor cages in a single room at a temperature between 16 and 20°C and relative humidity between 60 and 69%. Fluorescent lighting was automatically controlled to give a cycle of 14 hours light and 10 hours darkness.
Environmental conditions were monitored and recorded twice daily on weekdays and once daily at week-ends.
The animals were allowed free access to mains drinking water and food (SQC Standard Rabbit Diet. Special Diets Services Ltd., Stepfield) throughout the study.
Filtered water was dispensed via an automatic system.
A certificate relating to the quality of the drinking water was issued by the Yorkshire Water Authority. The diet and drinking water were not considered to contain any contaminant at a level that might have affected the purpose or integrity of the study.
Allocation to treatment groups
No formal randomisation procedure was adopted. On arrival at the laboratory the animals were placed into holding cages, one at a time, as they came to hand from the delivery crates working along the battery from left to right and from top to bottom, until each cage contained a single animal. Each animal served as its own control.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye served as control
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 72 h
Reading time points: 1, 24, 48 and 72 h - Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- Treatment procedures
Each animal was held firmly but gently until quiet. A 'cup' was formed by gently pulling the lower lid of the left eye away from the eyeball and the test article (0.1 ml ) placed inside. Both the upper and lower lids were then held together for 1 - 2 seconds and the animal was released. The untreated right eye served as a control .
Irritation reactions were graded using the scale of Draize (Draize, J.H. (1959) Association of Food and Drug Officials of the U.S., Austin, Texas, "The Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics").
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritant / corrosive response data:
- No eye irritation was noted during the study period. The eye irritation scores were interpreted by a modified Kay and Calandra scoring system.
- Other effects:
- No other effects noted.
Any other information on results incl. tables
TABLE 1 Mean eye irritation scores
Mean scores | ||||
Time after treatment | Conjunctive (max 20) | Iris (max 10) | Cornea (max 80) | Mean total scores (max 110) |
1 hour | 0 | 0 | 0 | 0 |
1 day | 0 | 0 | 0 | 0 |
2 days | 0 | 0 | 0 | 0 |
3 days | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified - Executive summary:
A sample of propylene glycol diacetate was evaluated for eye irritation testing.
This material, when instilled into the eyes of three New Zealand White rabbits, produced no signs of irritation. The mean scores after 24, 48 and 72 hours were 0. Hence, no classification is required according to EU criteria.
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