Registration Dossier
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EC number: 214-244-2 | CAS number: 1117-31-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 (72 h): > 100 mg/L (nominal) and > 60 mg/L (geometric mean) for Pseudokirchneriella subcapitata (OECD 201)
NOEC (72 h): ≥ 100 mg/L (nominal) and ≥ 60 mg/L (geometric mean) for Pseudokirchneriella subcapitata (OECD 201)
Key value for chemical safety assessment
Additional information
One GLP Guideline study is available investigating the effects of 1,3-butylene diacetate (CAS 1117-31-3) to aquatic algae (Vryenhoef, 2012). The study was performed according to OECD 201 with the freshwater algae Pseudokirchneriella subcapitata. A range-finding test was performed in order to define the exposure concentrations for the definitive test. Concentrations of 0.1, 1.0, 10 and 100 mg/L did not result in any effects on growth rate after 72 h. Thus, a limit test with 100 mg/L was performed. No effects on the growth rate were observed in the definitive test as well. Thus, the ErC50 (72 h) was determined to be > 100 mg/L (nominal). Chemical analysis of the test substance concentration showed that the concentration of test substance dropped from 107% of nominal at 0 h to 33% of nominal after 72 h. Therefore, the concentrations were related to the geometric mean measured concentrations to derive the EC50 value. In this case, the ErC50 (72 h) was determined to be > 60 mg/L (geometric mean) based on the growth inhibition. The decline of test concentrations was probably related to instability of test substance.
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