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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Test material

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
animal:
Time point:
24/48/72 h
Score:
> 0 - < 2
Max. score:
2
Reversibility:
not specified
Irritation parameter:
cornea opacity score
Basis:
animal:
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
animal:
Time point:
24/48/72 h
Score:
0
Max. score:
10
Irritation parameter:
chemosis score
Basis:
animal:
Time point:
24/48/72 h
Score:
0
Max. score:
4

Applicant's summary and conclusion

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