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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

MAES, 2-(acryloyloxy)ethyl hydrogen succinate, is readily hydrolized and metabolites are excreted in urine or as carbondioxice by respiration.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

MAES is 2-(acryloyloxy)ethyl hydrogen succinate, molecular 216. It is an involatile liquid at room temperature, freezing at -17°C and decomposing at 139°C. The substance is soluble in water (solubility 162 g/L). It has a log Pow of 0.254. It is very slowly hydrolysed in acid (half life 295 d at pH 4 and 25°C), but relatively readily hydrolysed in alkali (half life 46.5 h at pH 9 and 25°C).

The toxicity information indicates that the substance is harmful if swallowed. Although there was no evidence of corrosivity in the TER test, the substance was corrosive in a conventional skin sensitisation assay. In the 28 day repeated dose study effects were seen in the stomach (acanthosis/hyperkeratosis) at 150 and 300 mg/kg bw/d and, in males at all dose levels (15, 150 and 1000 mg/kg bw/d) , duodenum (mucosal hypertrophy). Systemic effects were only seen at 300 mg/kg bw/d, suggesting they were secondary to the effects at the site of administration (the stomach) due to the corrosive nature of the administered substance and/or hydrolysis products, and in the duodenum of males, possibly due to the corrosivity being enhanced as hydrolysis is speeded as the pH of the gastro-intestinal tract content is raised. The substance was negative in a bacterial reverse mutation assay and a mouse micronucleus assay for genotoxicity, but positive in a chromosomal aberration study in vitro.

One possible hydrolysis product may be acrylic acid. Acrylic acid is also known to be harmful if swallowed and corrosive and is listed on Annex 1 to Directive 67/548/EEC as harmful - R20/21/22 (harmful if swallowed, in contract with skin and by inhalation) and corrosive - R35 (causes severe burns).