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EC number: 442-300-8 | CAS number: -
A GLP compliant study according to OECD guideline 423 and according to Method B1 of the Commission Directive 96/54/EC was performed to assess the acute oral toxicity of the test material following a single oral administration in the Sprague-Dawley CD (Cri: CD® (SD) IGS BR) strain rat. A group of three fasted females was treated with the test material at a dose level of 2000 mg/kg bodyweight. This was followed by a group of three fasted males at the same dose level. The test material was administered orally and undiluted. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy. There were no deaths and no signs of systemic toxicity. All animals showed expected gains in bodyweight over the study period. No abnormalities were noted at necropsy. In conclusion, The acute oral median lethal dose (LD50) of the test material in the Sprague-Dawley CD (Cri: CD® (SD) IGS BR) strain rat was estimated as being greater than 2000 mg/kg bodyweight.
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